Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

Conor McCafferty, Xavier Busuttil-Crellin, Tengyi Cai, Paul Monagle, Neil A. Goldenberg, Vera Ignjatovic

Research output: Contribution to journalComment/debate

Abstract

This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.

Original languageEnglish (US)
Pages (from-to)S29-S36
JournalJournal of Pediatrics
Volume221
DOIs
StatePublished - Jun 2020

Keywords

  • hemostasis
  • pediatrics
  • plasma
  • platelet
  • proteomics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis'. Together they form a unique fingerprint.

  • Cite this