Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia

Joel Kleinman, Daniel Weinberger, Alan D. Rogol, Llewellyn B. Bigelow, Susan T. Klein, J. Christian Gillin, Richard Jed Wyatt

Research output: Contribution to journalArticle

Abstract

Plasma prolactin concentrations in 17 drug-free chronic schizophrenic patients correlated inversely with ratings of their psychopathology. An inverse relationship between psychotic symptoms and plasma prolactin concentrations was particularly clear in patients with normal cerebral ventricular size as determined by computed tomography. The psychosis-prolactin relationship did not hold for schizophrenic patients with large ventricular size. These data suggest that the degree of psychosis is related to dopaminergic activity insofar as this is reflected by plasma prolactin concentrations, especially in schizophrenic patients with normal ventricular size. These findings lend further support to the hypothesis that ventricular size is a meaningful factor in subtyping chronic schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)655-657
Number of pages3
JournalArchives of General Psychiatry
Volume39
Issue number6
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Psychopathology
Prolactin
Schizophrenia
Psychotic Disorders
Tomography
Plasma
Pharmaceutical Preparations
Psychosis

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia. / Kleinman, Joel; Weinberger, Daniel; Rogol, Alan D.; Bigelow, Llewellyn B.; Klein, Susan T.; Gillin, J. Christian; Jed Wyatt, Richard.

In: Archives of General Psychiatry, Vol. 39, No. 6, 1982, p. 655-657.

Research output: Contribution to journalArticle

Kleinman, Joel ; Weinberger, Daniel ; Rogol, Alan D. ; Bigelow, Llewellyn B. ; Klein, Susan T. ; Gillin, J. Christian ; Jed Wyatt, Richard. / Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia. In: Archives of General Psychiatry. 1982 ; Vol. 39, No. 6. pp. 655-657.
@article{49e748473bc744f6941603fc13c52223,
title = "Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia",
abstract = "Plasma prolactin concentrations in 17 drug-free chronic schizophrenic patients correlated inversely with ratings of their psychopathology. An inverse relationship between psychotic symptoms and plasma prolactin concentrations was particularly clear in patients with normal cerebral ventricular size as determined by computed tomography. The psychosis-prolactin relationship did not hold for schizophrenic patients with large ventricular size. These data suggest that the degree of psychosis is related to dopaminergic activity insofar as this is reflected by plasma prolactin concentrations, especially in schizophrenic patients with normal ventricular size. These findings lend further support to the hypothesis that ventricular size is a meaningful factor in subtyping chronic schizophrenic patients.",
author = "Joel Kleinman and Daniel Weinberger and Rogol, {Alan D.} and Bigelow, {Llewellyn B.} and Klein, {Susan T.} and Gillin, {J. Christian} and {Jed Wyatt}, Richard",
year = "1982",
doi = "10.1001/archpsyc.1982.04290060017004",
language = "English (US)",
volume = "39",
pages = "655--657",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "6",

}

TY - JOUR

T1 - Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia

AU - Kleinman, Joel

AU - Weinberger, Daniel

AU - Rogol, Alan D.

AU - Bigelow, Llewellyn B.

AU - Klein, Susan T.

AU - Gillin, J. Christian

AU - Jed Wyatt, Richard

PY - 1982

Y1 - 1982

N2 - Plasma prolactin concentrations in 17 drug-free chronic schizophrenic patients correlated inversely with ratings of their psychopathology. An inverse relationship between psychotic symptoms and plasma prolactin concentrations was particularly clear in patients with normal cerebral ventricular size as determined by computed tomography. The psychosis-prolactin relationship did not hold for schizophrenic patients with large ventricular size. These data suggest that the degree of psychosis is related to dopaminergic activity insofar as this is reflected by plasma prolactin concentrations, especially in schizophrenic patients with normal ventricular size. These findings lend further support to the hypothesis that ventricular size is a meaningful factor in subtyping chronic schizophrenic patients.

AB - Plasma prolactin concentrations in 17 drug-free chronic schizophrenic patients correlated inversely with ratings of their psychopathology. An inverse relationship between psychotic symptoms and plasma prolactin concentrations was particularly clear in patients with normal cerebral ventricular size as determined by computed tomography. The psychosis-prolactin relationship did not hold for schizophrenic patients with large ventricular size. These data suggest that the degree of psychosis is related to dopaminergic activity insofar as this is reflected by plasma prolactin concentrations, especially in schizophrenic patients with normal ventricular size. These findings lend further support to the hypothesis that ventricular size is a meaningful factor in subtyping chronic schizophrenic patients.

UR - http://www.scopus.com/inward/record.url?scp=0019980287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019980287&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.1982.04290060017004

DO - 10.1001/archpsyc.1982.04290060017004

M3 - Article

C2 - 6979991

AN - SCOPUS:0019980287

VL - 39

SP - 655

EP - 657

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 6

ER -