Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia

The Canadian study of health and aging

Thierry Comlan Marc Medehouenou, Pierre Ayotte, Pierre Hugues Carmichael, Edeltraut Kröger, René Verreault, Joan Lindsay, Éric Dewailly, Suzanne L. Tyas, Alexandre Bureau, Danielle Laurin

Research output: Contribution to journalArticle

Abstract

Background: Even though polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are recognized as neurotoxicants, few studies have investigated their associations with dementia. Here, we assess associations of plasma PCB and OC pesticide concentrations with all-cause dementia and Alzheimer's disease (AD). Methods: Analyses are based on data from the Canadian Study of Health and Aging, a population-based study of men and women aged 65. + years at baseline. PCB and OC pesticide concentrations were measured in 2023 participants who had complete clinical evaluations and blood samples; 574 had dementia, including 399 cases of AD. Concentrations were log-transformed and used as continuous variables in logistic regression models to assess their individual associations with dementia and AD. Results: After adjustment for blood collection period, total plasma lipids, age, sex, education, apolipoprotein E e4 allele (ApoE4), tobacco and alcohol use, rural/urban residence, and comorbidities, elevated plasma PCB concentrations were not associated with increased prevalence of dementia and AD. Elevated concentrations of some OC pesticides and metabolites such as hexachlorobenzene, cis-nonachlor and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane were significantly associated with a reduced prevalence of dementia. A significant reduced prevalence of AD was also observed with elevated hexachlorobenzene concentrations. Other OC pesticides and metabolites were not associated with the prevalence of dementia or AD. No effect modification by sex and ApoE4 was observed for either dementia or AD. Conclusions: Elevated plasma PCB and OC pesticide concentrations were not associated with higher prevalence of all-cause dementia and AD. The possibility of modest reductions in prevalence with specific OC pesticides remains to be further investigated given the cross-sectional design of this study.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalEnvironment International
Volume69
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

PCB
plasma
hexachlorobenzene
metabolite
blood
organochlorine pesticide
health
ethane
tobacco
alcohol
logistics
allele
lipid
education

Keywords

  • Alzheimer disease
  • Dementia
  • Exposure
  • Organochlorine pesticide
  • Polychlorinated biphenyl

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Medehouenou, T. C. M., Ayotte, P., Carmichael, P. H., Kröger, E., Verreault, R., Lindsay, J., ... Laurin, D. (2014). Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia: The Canadian study of health and aging. Environment International, 69, 141-147. https://doi.org/10.1016/j.envint.2014.04.016

Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia : The Canadian study of health and aging. / Medehouenou, Thierry Comlan Marc; Ayotte, Pierre; Carmichael, Pierre Hugues; Kröger, Edeltraut; Verreault, René; Lindsay, Joan; Dewailly, Éric; Tyas, Suzanne L.; Bureau, Alexandre; Laurin, Danielle.

In: Environment International, Vol. 69, 01.01.2014, p. 141-147.

Research output: Contribution to journalArticle

Medehouenou, TCM, Ayotte, P, Carmichael, PH, Kröger, E, Verreault, R, Lindsay, J, Dewailly, É, Tyas, SL, Bureau, A & Laurin, D 2014, 'Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia: The Canadian study of health and aging', Environment International, vol. 69, pp. 141-147. https://doi.org/10.1016/j.envint.2014.04.016
Medehouenou, Thierry Comlan Marc ; Ayotte, Pierre ; Carmichael, Pierre Hugues ; Kröger, Edeltraut ; Verreault, René ; Lindsay, Joan ; Dewailly, Éric ; Tyas, Suzanne L. ; Bureau, Alexandre ; Laurin, Danielle. / Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia : The Canadian study of health and aging. In: Environment International. 2014 ; Vol. 69. pp. 141-147.
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