Plasma norepinephrine responses to cold challenge in depressed patients and normal controls

Alec Roy, Sally Guthrie, David Pickar, Markku Linnoila

Research output: Contribution to journalArticle

Abstract

Thirty depressed patients were compared with 39 controls for their plasma norepinephrine (NE) levels in relation to a cold challenge (placing a hand in ice cold water for 1 minute). Depressed patients showed significantly higher plasma NE levels than controls. Unipolar, but not bipolar patients, had significantly higher plasma NE levels than age- and sex-matched controls. Unipolar melancholic patients who were nonsuppressors on the dexamethasone suppression test showed a strong trend to have higher plasma NE levels than suppressors. These results are further evidence that the NE system is dysregulated in depression.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalPsychiatry Research
Volume21
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • cold challenge
  • depression
  • norepinephrine
  • Plasma

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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