Plasma nitrite response in older women to a physical function test

Devon A. Dobrosielski, Tennille Presley, Andreas Perlegas, Anthony P. Marsh, Daniel Kim-Shapiro, W. Jack Rejeski

Research output: Contribution to journalArticle

Abstract

Background and aims: Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults. Methods: Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence. Results: Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004). Conclusions: These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalAging clinical and experimental research
Volume22
Issue number5-6
DOIs
StatePublished - Oct 2010

Fingerprint

Nitrites
Nitric Oxide
Health
Luminescence
Biological Availability
Blood Vessels
Heparin
Skeletal Muscle

Keywords

  • 400 Meter walk
  • Acute exercise
  • Nitric oxide
  • Plasma nitrite

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Dobrosielski, D. A., Presley, T., Perlegas, A., Marsh, A. P., Kim-Shapiro, D., & Rejeski, W. J. (2010). Plasma nitrite response in older women to a physical function test. Aging clinical and experimental research, 22(5-6), 383-386. https://doi.org/10.3275/6734

Plasma nitrite response in older women to a physical function test. / Dobrosielski, Devon A.; Presley, Tennille; Perlegas, Andreas; Marsh, Anthony P.; Kim-Shapiro, Daniel; Rejeski, W. Jack.

In: Aging clinical and experimental research, Vol. 22, No. 5-6, 10.2010, p. 383-386.

Research output: Contribution to journalArticle

Dobrosielski, DA, Presley, T, Perlegas, A, Marsh, AP, Kim-Shapiro, D & Rejeski, WJ 2010, 'Plasma nitrite response in older women to a physical function test', Aging clinical and experimental research, vol. 22, no. 5-6, pp. 383-386. https://doi.org/10.3275/6734
Dobrosielski DA, Presley T, Perlegas A, Marsh AP, Kim-Shapiro D, Rejeski WJ. Plasma nitrite response in older women to a physical function test. Aging clinical and experimental research. 2010 Oct;22(5-6):383-386. https://doi.org/10.3275/6734
Dobrosielski, Devon A. ; Presley, Tennille ; Perlegas, Andreas ; Marsh, Anthony P. ; Kim-Shapiro, Daniel ; Rejeski, W. Jack. / Plasma nitrite response in older women to a physical function test. In: Aging clinical and experimental research. 2010 ; Vol. 22, No. 5-6. pp. 383-386.
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