Plasma metabolomics and lipidomics signatures of motoric cognitive risk syndrome in community-dwelling older adults

Wanmeng Li, Xuelian Sun, Yu Liu, Meiling Ge, Ying Lu, Xiaolei Liu, Lixing Zhou, Xiaohui Liu, Biao Dong, Jirong Yue, Qianli Xue, Lunzhi Dai, Birong Dong

Research output: Contribution to journalArticlepeer-review


Introduction: Motoric cognitive risk syndrome (MCR) is characterized by subjective cognitive complaints (SCCs) and slow gait (SG). Metabolomics and lipidomics may potentiate disclosure of the underlying mechanisms of MCR. Methods: This was a cross-sectional study from the West China Health and Aging Trend cohort study (WCHAT). The operational definition of MCR is the presence of SCCs and SG without dementia or mobility disability. The test and analysis were based on untargeted metabolomics and lipidomics, consensus clustering, lasso regression and 10-fold cross-validation. Results: This study enrolled 6,031 individuals for clinical analysis and 577 plasma samples for omics analysis. The overall prevalence of MCR was 9.7%, and the prevalence of MCR-only, assessed cognitive impairment-only (CI-only) and MCR-CI were 7.5, 13.3, and 2.1%, respectively. By consensus clustering analysis, MCR-only was clustered into three metabolic subtypes, MCR-I, MCR-II and MCR-III. Clinically, body fat mass (OR = 0.89, CI = 0.82–0.96) was negatively correlated with MCR-I, and comorbidity (OR = 2.19, CI = 1.10–4.38) was positively correlated with MCR-III. Diabetes mellitus had the highest ORs above 1 in MCR-II and MCR-III (OR = 3.18, CI = 1.02–9.91; OR = 2.83, CI = 1.33–6.04, respectively). The risk metabolites of MCR-III showed relatively high similarity with those of cognitive impairment. Notably, L-proline, L-cystine, ADMA, and N1-acetylspermidine were significantly changed in MCR-only, and PC(40:3), SM(32:1), TG(51:3), eicosanoic acid(20:1), methyl-D-galactoside and TG(50:3) contributed most to the prediction model for MCR-III. Interpretation: Pre-dementia syndrome of MCR has distinct metabolic subtypes, and SCCs and SG may cause different metabolic changes to develop MCR.

Original languageEnglish (US)
Article number977191
JournalFrontiers in Aging Neuroscience
StatePublished - Sep 7 2022


  • cross-sectional study
  • metabolomics and lipidomics
  • motoric cognitive risk syndrome
  • pre-dementia
  • slow gait speed
  • subjective cognitive complaint

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience


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