Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

Ravell Juan, Isaac Otim, Hadijah Nabalende, Ismail D. Legason, Steven James Reynolds, Martin D. Ogwang, Christopher M. Ndugwa, Vickie Marshall, Denise Whitby, James J. Goedert, Eric A. Engels, Kishor Bhatia, Michael J. Lenardo, Sam M. Mbulaiteye

Research output: Contribution to journalArticle

Abstract

Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalCancer Epidemiology
Volume52
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Fingerprint

Uganda
Burkitt Lymphoma
Human Herpesvirus 4
Magnesium
X-Linked Genetic Diseases
Odds Ratio
T-Lymphocytes
Viral Load
Malaria
Lymphoma
Age Groups
Tissue Donors
Pediatrics

Keywords

  • Africa
  • Burkitt lymphoma
  • Epidemiology
  • Epstein-Barr virus
  • Magnesium
  • XMEN

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda. / Juan, Ravell; Otim, Isaac; Nabalende, Hadijah; Legason, Ismail D.; Reynolds, Steven James; Ogwang, Martin D.; Ndugwa, Christopher M.; Marshall, Vickie; Whitby, Denise; Goedert, James J.; Engels, Eric A.; Bhatia, Kishor; Lenardo, Michael J.; Mbulaiteye, Sam M.

In: Cancer Epidemiology, Vol. 52, 01.02.2018, p. 70-74.

Research output: Contribution to journalArticle

Juan, R, Otim, I, Nabalende, H, Legason, ID, Reynolds, SJ, Ogwang, MD, Ndugwa, CM, Marshall, V, Whitby, D, Goedert, JJ, Engels, EA, Bhatia, K, Lenardo, MJ & Mbulaiteye, SM 2018, 'Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda', Cancer Epidemiology, vol. 52, pp. 70-74. https://doi.org/10.1016/j.canep.2017.12.004
Juan, Ravell ; Otim, Isaac ; Nabalende, Hadijah ; Legason, Ismail D. ; Reynolds, Steven James ; Ogwang, Martin D. ; Ndugwa, Christopher M. ; Marshall, Vickie ; Whitby, Denise ; Goedert, James J. ; Engels, Eric A. ; Bhatia, Kishor ; Lenardo, Michael J. ; Mbulaiteye, Sam M. / Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda. In: Cancer Epidemiology. 2018 ; Vol. 52. pp. 70-74.
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abstract = "Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0{\%} vs. 35{\%}; odds ratio [OR] 11.3, 95{\%} CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0{\%} vs. 13.9{\%}; OR 3.61, 95{\%} CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.",
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T1 - Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

AU - Juan, Ravell

AU - Otim, Isaac

AU - Nabalende, Hadijah

AU - Legason, Ismail D.

AU - Reynolds, Steven James

AU - Ogwang, Martin D.

AU - Ndugwa, Christopher M.

AU - Marshall, Vickie

AU - Whitby, Denise

AU - Goedert, James J.

AU - Engels, Eric A.

AU - Bhatia, Kishor

AU - Lenardo, Michael J.

AU - Mbulaiteye, Sam M.

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N2 - Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.

AB - Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.

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