TY - JOUR
T1 - Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension
T2 - A Nested Case-Control Study
AU - Lin, Tengfei
AU - Bi, Chonglei
AU - Song, Yun
AU - Guo, Huiyuan
AU - Liu, Lishun
AU - Zhou, Ziyi
AU - Wang, Binyan
AU - Tang, Genfu
AU - Liu, Chengzhang
AU - Yang, Yan
AU - Ling, Wenhua
AU - Yang, Jingang
AU - Cui, Yimin
AU - Zhang, Chengguo
AU - Li, Gang
AU - Li, Jiaang
AU - Li, Jianping
AU - Zhang, Yan
AU - Huo, Yong
AU - Wang, Xiaobin
AU - Zhang, Hao
AU - Qin, Xianhui
AU - Xu, Xiping
N1 - Funding Information:
The study was supported by funding from the following: the National Key Research and Development Program (2016YFE0205400, 2018ZX09739010, 2018ZX09301034003), the Science and Technology Planning Project of Guangzhou, China (201707020010); the Science, Technology and Innovation Committee of Shenzhen (GJHS20170314114526143, JSGG20180703155802047); the Economic, Trade and Information Commission of Shenzhen Municipality (20170505161556110, 20170505160926390); the National Natural Science Foundation of China (81730019, 81973133); Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University (2017J009); and the 111 project from the Education Ministry of China (No. B18053).
PY - 2021/1
Y1 - 2021/1
N2 - Objective: The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. Methods: A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. Results: When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (<0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33-5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12-3.76), compared with those in quartile 3 (0.83 to <0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to <0.89 mmol/L among hypertensive adults.
AB - Objective: The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. Methods: A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. Results: When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (<0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33-5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12-3.76), compared with those in quartile 3 (0.83 to <0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to <0.89 mmol/L among hypertensive adults.
KW - Hypertension
KW - Incidence
KW - Incident cancer
KW - Magnesium
KW - Minerals
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U2 - 10.1159/000510214
DO - 10.1159/000510214
M3 - Article
C2 - 33271534
AN - SCOPUS:85097846835
VL - 76
SP - 304
EP - 312
JO - Annals of Nutrition and Metabolism
JF - Annals of Nutrition and Metabolism
SN - 0250-6807
IS - 5
ER -