@article{bb9a59d6d5f34ff697f1bf460c42e2cc,
title = "Plasma magnesium and the risk of new-onset hyperuricaemia in hypertensive patients",
abstract = "We aimed to evaluate the relationship of plasma Mg with the risk of new-onset hyperuricaemia and examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric acid (UA) Sub-study of the China Stroke Primary Prevention Trial (CSPPT). A total of 1685 participants were included in the present study. The main outcome was new-onset hyperuricaemia defined as a UA concentration ≥417 μmol/l in men or ≥357 μmol/l in women. The secondary outcome was a change in UA concentration defined as UA at the exit visit minus that at baseline. During a median follow-up duration of 4.3 years, new-onset hyperuricaemia occurred in 290 (17.2 %) participants. There was a significantly inverse relation of plasma Mg with the risk of new-onset hyperuricaemia (per sd increment; OR 0.85; 95 % CI 0.74, 0.99) and change in UA levels (per sd increment; β -3.96 μmol/l; 95 % CI -7.14, -0.79). Consistently, when plasma Mg was analysed as tertiles, a significantly lower risk of new-onset hyperuricaemia (OR 0.67; 95 % CI 0.48, 0.95) and less increase in UA levels (β -8.35 μmol/l; 95 % CI -16.12, -0.58) were found among participants in tertile 3 (≥885.5 μmol/l) compared with those in tertile 1 (<818.9 μmol/l). Similar trends were found in males and females. Higher plasma Mg levels were associated with a decreased risk of new-onset hyperuricaemia in hypertensive adults.",
keywords = "Hypertensive patients, Hyperuricaemia, Magnesium, Uric acid",
author = "Yuanyuan Zhang and Huan Li and Chongfei Jiang and Tengfei Lin and Ziyi Zhou and Yun Song and Chengzhang Liu and Lishun Liu and Binyan Wang and Jianping Li and Yan Zhang and Yimin Cui and Yong Huo and Xiaobin Wang and Hao Zhang and Xianhui Qin and Xiping Xu",
note = "Funding Information: Y. H. reports grants from the National Key Research and Development Program (2016YFC0903103). Y. C. reports grants from the National Key Research and Development Program (2016YFC0904900). X. X. reports grants from the National Key Research and Development Program (2016YFE0205400, 2018ZX09739010 and 2018ZX09301034003); the Science and Technology Planning Project of Guangzhou, China (201707020010); the Science, Technology and Innovation Committee of Shenzhen (JSGG20170412155639040 and GJHS20170314114526143); and the Economic, Trade and Information Commission of Shenzhen Municipality (20170505161556110 and 20170505160926390). X. Q. reports grants from the National Natural Science Foundation of China (81730019) and the Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University (2017J009). The remaining authors declare no conflicts of interest. Funding Information: The study was supported by funding from the following: the National Key Research and Development Program (2016YFE0205400, 2016YFC0903103, 2016YFC0904900, 2018ZX09739010 and 2018ZX09301034003), the Science and Technology Planning Project of Guangzhou, China (201707020010); the Science, Technology and Innovation Committee of Shenzhen (JSGG20170412155639040 and GJHS20170314114526143); the Economic, Trade and Information Commission of Shenzhen Municipality (20170505161556110 and 20170505160926390); the National Natural Science Foundation of China (81730019) and Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University (2017J009). Publisher Copyright: {\textcopyright} The Authors 2020.",
year = "2020",
doi = "10.1017/S0007114520001099",
language = "English (US)",
volume = "124",
pages = "156--163",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "2",
}