TY - JOUR
T1 - Plasma lipid peroxides
T2 - Relationships to cardiovascular risk factors and prevalent cardiovascular disease
AU - Rumley, A. G.
AU - Woodward, M.
AU - Rumley, A.
AU - Rumley, J.
AU - Lowe, G. D.O.
N1 - Funding Information:
This study was partly funded by the Chief Scientist Office, Department of Health, Scottish Office. The views expressed here are those of the authors and not necessarily of this office. The work was also supported by a grant from the British Heart Foundation.
PY - 2004/12
Y1 - 2004/12
N2 - Background: The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined. Aim: To study the relationships of plasma lipid peroxides to cardiovascular risk factors in a random population sample. Design: Random, age- and sex-stratified population sample. Methods: We studied 739 men and women aged 25-74 years. Lipid peroxides were assayed by the thiobarbituric acid (TBA) assay for malondialdehyde (MDA) in stored plasma samples. Results: Lipid peroxide levels increased with age. In men, lipid peroxides were significantly associated with smoking habit. Lipid peroxides correlated with non-fasting serum triglycerides (r=0.33; p<0.0001) in both sexes. Weaker associations were observed for cholesterol, high-density lipoprotein cholesterol (inversely), body mass index, fibrinogen and white cell count; as well as an inverse association with serum vitamin C in men. Discussion: These findings clarify the relationships of plasma lipid peroxides to cardiovascular risk factors; and are consistent with the hypothesis that lipid peroxidation may be one mechanism through which several risk factors may promote cardiovascular disease.
AB - Background: The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined. Aim: To study the relationships of plasma lipid peroxides to cardiovascular risk factors in a random population sample. Design: Random, age- and sex-stratified population sample. Methods: We studied 739 men and women aged 25-74 years. Lipid peroxides were assayed by the thiobarbituric acid (TBA) assay for malondialdehyde (MDA) in stored plasma samples. Results: Lipid peroxide levels increased with age. In men, lipid peroxides were significantly associated with smoking habit. Lipid peroxides correlated with non-fasting serum triglycerides (r=0.33; p<0.0001) in both sexes. Weaker associations were observed for cholesterol, high-density lipoprotein cholesterol (inversely), body mass index, fibrinogen and white cell count; as well as an inverse association with serum vitamin C in men. Discussion: These findings clarify the relationships of plasma lipid peroxides to cardiovascular risk factors; and are consistent with the hypothesis that lipid peroxidation may be one mechanism through which several risk factors may promote cardiovascular disease.
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U2 - 10.1093/qjmed/hch130
DO - 10.1093/qjmed/hch130
M3 - Article
C2 - 15569813
AN - SCOPUS:10244262721
SN - 1460-2725
VL - 97
SP - 809
EP - 816
JO - QJM - Monthly Journal of the Association of Physicians
JF - QJM - Monthly Journal of the Association of Physicians
IS - 12
ER -