Plasma levels of trazodone: Methodology and applications

D. R. Abernethy, D. J. Greenblatt, R. I. Shader

Research output: Contribution to journalArticlepeer-review

Abstract

A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method utilizes gas-liquid chromatography with nitrogen-phosphorus detection. Applicability of the method is demonstrated by (1) a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and (2) steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalPharmacology
Volume28
Issue number1
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Pharmacology

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