TY - JOUR
T1 - Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men
AU - Fedorova, Olga V.
AU - Lakatta, Edward G.
AU - Bagrov, Alexei Y.
AU - Melander, Olle
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2015/3/6
Y1 - 2015/3/6
N2 - OBJECTIVE:: Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity. METHODS:: Thirty-nine healthy individuals (53±11 years old; 20 men and 19 women) had a total daily NaCl intake of 50mmol (low-salt) and 150mmol (high-salt) for 4 weeks each, in a random order. ABP and MBG in plasma and urine were measured at baseline (unstandardized salt intake) and after high and low-salt intake. RESULTS:: At baseline, plasma MBG (P-MBG) was related to 24-h SBP (r=0.43, P=0.007) and DBP (r=0.32, P=0.047), whereas 24-h urinary excretion of MBG (UE-MBG) was related to 24-h DBP only (r=0.42, P=0.008). Sex-specific analyses revealed that these relationships were significant in men only. Compared with low-salt, high-salt diet increased P-MBG (P=0.029), mainly driven by results in men. Male P-MBG responders vs. nonresponders (above vs. below median of high-salt induced P-MBG increase) had markedly enhanced SBP (10.4±6.4 vs. 1.0±6.0mmHg; P=0.003) and DBP (6.7±5.0 vs. -0.6±3.6mmHg; P=0.001) salt sensitivity. CONCLUSION:: In men, MBG increases with 24-h ABP, and similar to Dahl salt-sensitive rats, 4 weeks of high-salt induced MBG response is accompanied by marked salt sensitivity. However, these patterns seem to be sex-specific and are not observed in women.
AB - OBJECTIVE:: Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity. METHODS:: Thirty-nine healthy individuals (53±11 years old; 20 men and 19 women) had a total daily NaCl intake of 50mmol (low-salt) and 150mmol (high-salt) for 4 weeks each, in a random order. ABP and MBG in plasma and urine were measured at baseline (unstandardized salt intake) and after high and low-salt intake. RESULTS:: At baseline, plasma MBG (P-MBG) was related to 24-h SBP (r=0.43, P=0.007) and DBP (r=0.32, P=0.047), whereas 24-h urinary excretion of MBG (UE-MBG) was related to 24-h DBP only (r=0.42, P=0.008). Sex-specific analyses revealed that these relationships were significant in men only. Compared with low-salt, high-salt diet increased P-MBG (P=0.029), mainly driven by results in men. Male P-MBG responders vs. nonresponders (above vs. below median of high-salt induced P-MBG increase) had markedly enhanced SBP (10.4±6.4 vs. 1.0±6.0mmHg; P=0.003) and DBP (6.7±5.0 vs. -0.6±3.6mmHg; P=0.001) salt sensitivity. CONCLUSION:: In men, MBG increases with 24-h ABP, and similar to Dahl salt-sensitive rats, 4 weeks of high-salt induced MBG response is accompanied by marked salt sensitivity. However, these patterns seem to be sex-specific and are not observed in women.
KW - dietary sodium
KW - marinobufagenin
KW - salt sensitivity
KW - sex specificity
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U2 - 10.1097/HJH.0000000000000437
DO - 10.1097/HJH.0000000000000437
M3 - Article
C2 - 25479026
AN - SCOPUS:84922445412
VL - 33
SP - 534
EP - 541
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 3
ER -