Plasma homocysteine predicts progression of atherosclerosis

M. Leila Rasouli, Khurram Nasir, Roger S Blumenthal, Robert Park, Douglas C. Aziz, Matthew J. Budoff

Research output: Contribution to journalArticle

Abstract

Mini abstract: Three emerging risk factors potentially useful in predicting future cardiac events are electron-beam computed tomography (EBT), homocysteine(HCY), and C-reactive Protein (CRP). We evaluated a cohort of 133 serial asymptomatic patients, who underwent two consecutive EBT scans (8-84 months apart) and a comprehensive cardiac risk factor assessment, including measurements for lipids, ultrasensitive CRP and homocysteine. Individuals with elevated HCY (≥12 μmol/L) demonstrated a mean increase in CC progression of 35% per year, while those with HCY 12 μmol/L) strongly and independently predicts progression of coronary plaque burden. Background: Despite the availability of effective preventive therapies, coronary artery disease (CAD) remains the leading cause of morbidity and mortality. Use of traditional cardiovascular risk factors is imprecise and predicts less than one half of future cardiovascular events. Three 'emerging risk factors', as potential means of identifying subclinical atherosclerosis and predicting future cardiovascular events, are electron-beam computed tomography, homocysteine, and C-reactive protein. Given the evidence that HCY and CRP are involved in atherogenesis, we hypothesized that significant progression of EBT calcium score (a measure of atherosclerotic plaque burden) is associated with higher levels of these markers. Methods: We evaluated 133 asymptomatic patients (100 men, 33 women; mean age was 61 ± 9 years) who underwent previous EBT calcium score testing at Harbor-UCLA 8-80 months prior to enrollment (mean follow-up 20 months). Exclusion criteria included those with known or symptomatic CAD and chronic renal disease. During enrollment, we measured risk factors, serum HCY, serum lipids, ultrasensitive-CRP, and repeat EBT calcium scan. Statistical analysis was performed using probable Chi square method, and Student's t-test. Results: Individuals with elevated HCY (≥12 μmol/L) demonstrated a mean increase in CC progression of 35% per year, while those with HCY 12 μmol/L) strongly and independently predicts progression of coronary plaque burden.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalAtherosclerosis
Volume181
Issue number1
DOIs
StatePublished - Jul 2005

Fingerprint

Homocysteine
Atherosclerosis
X Ray Computed Tomography
C-Reactive Protein
Calcium
Coronary Artery Disease
Lipids
Atherosclerotic Plaques
Serum
Chronic Renal Insufficiency
Students
Morbidity
Mortality

Keywords

  • Atherosclerosis progression
  • Atherosclerotic plaque burden
  • C-reactive protein
  • Cardiac CT
  • Coronary artery disease
  • Plasma homocysteine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plasma homocysteine predicts progression of atherosclerosis. / Rasouli, M. Leila; Nasir, Khurram; Blumenthal, Roger S; Park, Robert; Aziz, Douglas C.; Budoff, Matthew J.

In: Atherosclerosis, Vol. 181, No. 1, 07.2005, p. 159-165.

Research output: Contribution to journalArticle

Rasouli, ML, Nasir, K, Blumenthal, RS, Park, R, Aziz, DC & Budoff, MJ 2005, 'Plasma homocysteine predicts progression of atherosclerosis', Atherosclerosis, vol. 181, no. 1, pp. 159-165. https://doi.org/10.1016/j.atherosclerosis.2005.01.001
Rasouli, M. Leila ; Nasir, Khurram ; Blumenthal, Roger S ; Park, Robert ; Aziz, Douglas C. ; Budoff, Matthew J. / Plasma homocysteine predicts progression of atherosclerosis. In: Atherosclerosis. 2005 ; Vol. 181, No. 1. pp. 159-165.
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AU - Rasouli, M. Leila

AU - Nasir, Khurram

AU - Blumenthal, Roger S

AU - Park, Robert

AU - Aziz, Douglas C.

AU - Budoff, Matthew J.

PY - 2005/7

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AB - Mini abstract: Three emerging risk factors potentially useful in predicting future cardiac events are electron-beam computed tomography (EBT), homocysteine(HCY), and C-reactive Protein (CRP). We evaluated a cohort of 133 serial asymptomatic patients, who underwent two consecutive EBT scans (8-84 months apart) and a comprehensive cardiac risk factor assessment, including measurements for lipids, ultrasensitive CRP and homocysteine. Individuals with elevated HCY (≥12 μmol/L) demonstrated a mean increase in CC progression of 35% per year, while those with HCY 12 μmol/L) strongly and independently predicts progression of coronary plaque burden. Background: Despite the availability of effective preventive therapies, coronary artery disease (CAD) remains the leading cause of morbidity and mortality. Use of traditional cardiovascular risk factors is imprecise and predicts less than one half of future cardiovascular events. Three 'emerging risk factors', as potential means of identifying subclinical atherosclerosis and predicting future cardiovascular events, are electron-beam computed tomography, homocysteine, and C-reactive protein. Given the evidence that HCY and CRP are involved in atherogenesis, we hypothesized that significant progression of EBT calcium score (a measure of atherosclerotic plaque burden) is associated with higher levels of these markers. Methods: We evaluated 133 asymptomatic patients (100 men, 33 women; mean age was 61 ± 9 years) who underwent previous EBT calcium score testing at Harbor-UCLA 8-80 months prior to enrollment (mean follow-up 20 months). Exclusion criteria included those with known or symptomatic CAD and chronic renal disease. During enrollment, we measured risk factors, serum HCY, serum lipids, ultrasensitive-CRP, and repeat EBT calcium scan. Statistical analysis was performed using probable Chi square method, and Student's t-test. Results: Individuals with elevated HCY (≥12 μmol/L) demonstrated a mean increase in CC progression of 35% per year, while those with HCY 12 μmol/L) strongly and independently predicts progression of coronary plaque burden.

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KW - Plasma homocysteine

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