Plasma homocysteine levels associated with a corrected QT interval

Zhao Li, Xiaofan Guo, Guozhe Sun, Liqiang Zheng, Yingxian Sun, Yamin Liu, Maria Roselle Abraham

Research output: Contribution to journalArticle

Abstract

Background: Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods: Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. Results: The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1-13.8umol/L; Q3: 13.8-18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95% CI: 1.05-1.43 for Q1; OR: 1.40, 95% CI: 1.19-1.65 for Q4). Conclusions: QTc interval was associated with the Hcy level in this general population.

LanguageEnglish (US)
Article number182
JournalBMC Cardiovascular Disorders
Volume17
Issue number1
DOIs
StatePublished - Jul 11 2017

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Homocysteine
Population
Electrocardiography
Logistic Models
Regression Analysis

Keywords

  • Cardiovascular disease
  • Corrected QT interval
  • Homocysteine
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Li, Z., Guo, X., Sun, G., Zheng, L., Sun, Y., Liu, Y., & Abraham, M. R. (2017). Plasma homocysteine levels associated with a corrected QT interval. BMC Cardiovascular Disorders, 17(1), [182]. DOI: 10.1186/s12872-017-0617-z

Plasma homocysteine levels associated with a corrected QT interval. / Li, Zhao; Guo, Xiaofan; Sun, Guozhe; Zheng, Liqiang; Sun, Yingxian; Liu, Yamin; Abraham, Maria Roselle.

In: BMC Cardiovascular Disorders, Vol. 17, No. 1, 182, 11.07.2017.

Research output: Contribution to journalArticle

Li, Z, Guo, X, Sun, G, Zheng, L, Sun, Y, Liu, Y & Abraham, MR 2017, 'Plasma homocysteine levels associated with a corrected QT interval' BMC Cardiovascular Disorders, vol 17, no. 1, 182. DOI: 10.1186/s12872-017-0617-z
Li Z, Guo X, Sun G, Zheng L, Sun Y, Liu Y et al. Plasma homocysteine levels associated with a corrected QT interval. BMC Cardiovascular Disorders. 2017 Jul 11;17(1). 182. Available from, DOI: 10.1186/s12872-017-0617-z
Li, Zhao ; Guo, Xiaofan ; Sun, Guozhe ; Zheng, Liqiang ; Sun, Yingxian ; Liu, Yamin ; Abraham, Maria Roselle. / Plasma homocysteine levels associated with a corrected QT interval. In: BMC Cardiovascular Disorders. 2017 ; Vol. 17, No. 1.
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abstract = "Background: Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods: Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. Results: The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1-13.8umol/L; Q3: 13.8-18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95\{%} CI: 1.05-1.43 for Q1; OR: 1.40, 95\{%} CI: 1.19-1.65 for Q4). Conclusions: QTc interval was associated with the Hcy level in this general population.",
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