Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study.

R. Beaglehole, D. C. Trost, I. Tamir, P. Kwiterovich, C. J. Glueck, W. Insull, B. Christensen

Research output: Contribution to journalArticle

Abstract

We examined the decline in high-density lipoprotein cholesterol in adolescent males and the postadolescent sex differences in HDL cholesterol levels. Prevalence data are presented for 1639 white males and females ages 6-25 years from six populations of the Lipid Research Clinics Program. The association of HDL cholesterol with age, smoking habits, and anthropometric, clinical chemistry and nutritional variables was examined by correlation and regression analyses. Although mean HDL cholesterol levels in children ages 6-10 years were lower in females than in males, HDL cholesterol levels gradually increased with age in females, while in males the mean HDL cholesterol levels declined form 55.9 mg/dl at ages 6-10 years to 45.5 mg/dl at ages 18-25 years. In young adults, HDL cholesterol levels were an average of 10.5 mg/dl higher in females than in males. In the 6-10-year-old age group, none of the study variables was significantly associated with HDL cholesterol. In the 11-17-year-old subjects, significant associations were noted with several variables, especially in the males. The strongest association was an inverse association with weight in males. In the young adults ages 18-25 years, significant inverse associations were found with weight and alkaline phosphatase in both sexes and with sucrose and smoking in females. The data suggested that the most important influence on HDL cholesterol levels in adolescent males are changes in gonadal hormone levels and that some of the factors known to influence HDL cholesterol levels in older adults are already associated with HDL cholesterol in adolescents and young adults.

Original languageEnglish (US)
JournalCirculation
Volume62
Issue number4 Pt 2
StatePublished - Nov 1980
Externally publishedYes

Fingerprint

HDL Cholesterol
Young Adult
Cross-Sectional Studies
Lipids
Research
Smoking
Gonadal Hormones
Weights and Measures
Clinical Chemistry
Sex Characteristics
Habits
Alkaline Phosphatase
Sucrose
Age Groups
Regression Analysis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Beaglehole, R., Trost, D. C., Tamir, I., Kwiterovich, P., Glueck, C. J., Insull, W., & Christensen, B. (1980). Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study. Circulation, 62(4 Pt 2).

Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study. / Beaglehole, R.; Trost, D. C.; Tamir, I.; Kwiterovich, P.; Glueck, C. J.; Insull, W.; Christensen, B.

In: Circulation, Vol. 62, No. 4 Pt 2, 11.1980.

Research output: Contribution to journalArticle

Beaglehole, R, Trost, DC, Tamir, I, Kwiterovich, P, Glueck, CJ, Insull, W & Christensen, B 1980, 'Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study.', Circulation, vol. 62, no. 4 Pt 2.
Beaglehole R, Trost DC, Tamir I, Kwiterovich P, Glueck CJ, Insull W et al. Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2).
Beaglehole, R. ; Trost, D. C. ; Tamir, I. ; Kwiterovich, P. ; Glueck, C. J. ; Insull, W. ; Christensen, B. / Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study. In: Circulation. 1980 ; Vol. 62, No. 4 Pt 2.
@article{6d008f3c880448b0998094cde384952c,
title = "Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study.",
abstract = "We examined the decline in high-density lipoprotein cholesterol in adolescent males and the postadolescent sex differences in HDL cholesterol levels. Prevalence data are presented for 1639 white males and females ages 6-25 years from six populations of the Lipid Research Clinics Program. The association of HDL cholesterol with age, smoking habits, and anthropometric, clinical chemistry and nutritional variables was examined by correlation and regression analyses. Although mean HDL cholesterol levels in children ages 6-10 years were lower in females than in males, HDL cholesterol levels gradually increased with age in females, while in males the mean HDL cholesterol levels declined form 55.9 mg/dl at ages 6-10 years to 45.5 mg/dl at ages 18-25 years. In young adults, HDL cholesterol levels were an average of 10.5 mg/dl higher in females than in males. In the 6-10-year-old age group, none of the study variables was significantly associated with HDL cholesterol. In the 11-17-year-old subjects, significant associations were noted with several variables, especially in the males. The strongest association was an inverse association with weight in males. In the young adults ages 18-25 years, significant inverse associations were found with weight and alkaline phosphatase in both sexes and with sucrose and smoking in females. The data suggested that the most important influence on HDL cholesterol levels in adolescent males are changes in gonadal hormone levels and that some of the factors known to influence HDL cholesterol levels in older adults are already associated with HDL cholesterol in adolescents and young adults.",
author = "R. Beaglehole and Trost, {D. C.} and I. Tamir and P. Kwiterovich and Glueck, {C. J.} and W. Insull and B. Christensen",
year = "1980",
month = "11",
language = "English (US)",
volume = "62",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "4 Pt 2",

}

TY - JOUR

T1 - Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study.

AU - Beaglehole, R.

AU - Trost, D. C.

AU - Tamir, I.

AU - Kwiterovich, P.

AU - Glueck, C. J.

AU - Insull, W.

AU - Christensen, B.

PY - 1980/11

Y1 - 1980/11

N2 - We examined the decline in high-density lipoprotein cholesterol in adolescent males and the postadolescent sex differences in HDL cholesterol levels. Prevalence data are presented for 1639 white males and females ages 6-25 years from six populations of the Lipid Research Clinics Program. The association of HDL cholesterol with age, smoking habits, and anthropometric, clinical chemistry and nutritional variables was examined by correlation and regression analyses. Although mean HDL cholesterol levels in children ages 6-10 years were lower in females than in males, HDL cholesterol levels gradually increased with age in females, while in males the mean HDL cholesterol levels declined form 55.9 mg/dl at ages 6-10 years to 45.5 mg/dl at ages 18-25 years. In young adults, HDL cholesterol levels were an average of 10.5 mg/dl higher in females than in males. In the 6-10-year-old age group, none of the study variables was significantly associated with HDL cholesterol. In the 11-17-year-old subjects, significant associations were noted with several variables, especially in the males. The strongest association was an inverse association with weight in males. In the young adults ages 18-25 years, significant inverse associations were found with weight and alkaline phosphatase in both sexes and with sucrose and smoking in females. The data suggested that the most important influence on HDL cholesterol levels in adolescent males are changes in gonadal hormone levels and that some of the factors known to influence HDL cholesterol levels in older adults are already associated with HDL cholesterol in adolescents and young adults.

AB - We examined the decline in high-density lipoprotein cholesterol in adolescent males and the postadolescent sex differences in HDL cholesterol levels. Prevalence data are presented for 1639 white males and females ages 6-25 years from six populations of the Lipid Research Clinics Program. The association of HDL cholesterol with age, smoking habits, and anthropometric, clinical chemistry and nutritional variables was examined by correlation and regression analyses. Although mean HDL cholesterol levels in children ages 6-10 years were lower in females than in males, HDL cholesterol levels gradually increased with age in females, while in males the mean HDL cholesterol levels declined form 55.9 mg/dl at ages 6-10 years to 45.5 mg/dl at ages 18-25 years. In young adults, HDL cholesterol levels were an average of 10.5 mg/dl higher in females than in males. In the 6-10-year-old age group, none of the study variables was significantly associated with HDL cholesterol. In the 11-17-year-old subjects, significant associations were noted with several variables, especially in the males. The strongest association was an inverse association with weight in males. In the young adults ages 18-25 years, significant inverse associations were found with weight and alkaline phosphatase in both sexes and with sucrose and smoking in females. The data suggested that the most important influence on HDL cholesterol levels in adolescent males are changes in gonadal hormone levels and that some of the factors known to influence HDL cholesterol levels in older adults are already associated with HDL cholesterol in adolescents and young adults.

UR - http://www.scopus.com/inward/record.url?scp=0019080576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019080576&partnerID=8YFLogxK

M3 - Article

C2 - 7418147

AN - SCOPUS:0019080576

VL - 62

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 4 Pt 2

ER -