Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study

A. J. Fiocco, A. M. Kanaya, K. M. Lindquist, T. B. Harris, S. Satterfield, E. M. Simonsick, L. Kuller, C. Rosano, K. Yaffe

Research output: Contribution to journalArticlepeer-review

Abstract

F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume84
Issue number1-2
DOIs
StatePublished - Jan 2011
Externally publishedYes

Keywords

  • Aging
  • Biomarker
  • Cognition
  • Cohort

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Fingerprint

Dive into the research topics of 'Plasma F<sub>2</sub>-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study'. Together they form a unique fingerprint.

Cite this