Plasma-free homovanillic acid: Within- and across-day stability in children and adults with tourette's syndrome

Mark A. Riddle; James F. Leckman; George M. Anderson; Sharon I. Ort; Maureen T. Hardin; John Stevenson; Donald J. Cohen

doi:10.1016/0024-3205(87)90004-X

Plasma-free homovanillic acid: Within- and across-day stability in children and adults with tourette's syndrome

Mark A. Riddle, James F. Leckman, George M. Anderson, Sharon I. Ort, Maureen T. Hardin, John Stevenson, Donald J. Cohen

Research output: Contribution to journal › Article › peer-review

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Abstract

Within- and across-day stability of plasma-free homovanillic acid (pHVA) was assessed in children and adults with Tourette's syndrome. A diurnal fall in pHVA was observed in 13 of 15 subjects. There was a small but significant (p < .0001) decrease (8%) in mean morning pHVA levels obtained just 20 minutes apart (8:30 A.M. and 8:50 A.M.). A substantial and significant (p < .001) mean decrease in pHVA (25%) was observed when samples obtained between 8:00 and 8:30 A.M. were compared with samples obtained at 12:00 noon. Changes in pHVA levels observed during the afternoon (between 12:00 noon and 4:00 P.M.) were small, nondirectional, and nonsignificant. Repeated measurement of morning pHVA in the same individual after 24 or more hours revealed marked increases or decreases in many individuals, suggesting that morning pHVA is not a stable measure. The results of this and previous studies suggest that pHVA obtained at 12:00 noon or later in the day may be a more reliable measure of centrally produced HVA. Further studies are needed regarding the stability of pHVA over time.

Original language	English (US)
Pages (from-to)	2145-2151
Number of pages	7
Journal	Life Sciences
Volume	40
Issue number	22
DOIs	https://doi.org/10.1016/0024-3205(87)90004-X
State	Published - Jun 1 1987
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(87)90004-X

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title = "Plasma-free homovanillic acid: Within- and across-day stability in children and adults with tourette's syndrome",

abstract = "Within- and across-day stability of plasma-free homovanillic acid (pHVA) was assessed in children and adults with Tourette's syndrome. A diurnal fall in pHVA was observed in 13 of 15 subjects. There was a small but significant (p < .0001) decrease (8%) in mean morning pHVA levels obtained just 20 minutes apart (8:30 A.M. and 8:50 A.M.). A substantial and significant (p < .001) mean decrease in pHVA (25%) was observed when samples obtained between 8:00 and 8:30 A.M. were compared with samples obtained at 12:00 noon. Changes in pHVA levels observed during the afternoon (between 12:00 noon and 4:00 P.M.) were small, nondirectional, and nonsignificant. Repeated measurement of morning pHVA in the same individual after 24 or more hours revealed marked increases or decreases in many individuals, suggesting that morning pHVA is not a stable measure. The results of this and previous studies suggest that pHVA obtained at 12:00 noon or later in the day may be a more reliable measure of centrally produced HVA. Further studies are needed regarding the stability of pHVA over time.",

author = "Riddle, {Mark A.} and Leckman, {James F.} and Anderson, {George M.} and Ort, {Sharon I.} and Hardin, {Maureen T.} and John Stevenson and Cohen, {Donald J.}",

note = "Funding Information: The research was supported in part by USPHS grant 5-F32-MH09109, MHCRC grant MH30929, NIH grant RR00125, NICHD grant HD03008, the Tourette Syndrome Association, the Solomon R. & Rebecca D. Baker Foundation, Inc., Mr. Leonard Berger, the Gateposts Foundation, and the John Merck Fund.",

year = "1987",

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doi = "10.1016/0024-3205(87)90004-X",

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pages = "2145--2151",

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T1 - Plasma-free homovanillic acid

T2 - Within- and across-day stability in children and adults with tourette's syndrome

AU - Riddle, Mark A.

AU - Leckman, James F.

AU - Anderson, George M.

AU - Ort, Sharon I.

AU - Hardin, Maureen T.

AU - Stevenson, John

AU - Cohen, Donald J.

N1 - Funding Information: The research was supported in part by USPHS grant 5-F32-MH09109, MHCRC grant MH30929, NIH grant RR00125, NICHD grant HD03008, the Tourette Syndrome Association, the Solomon R. & Rebecca D. Baker Foundation, Inc., Mr. Leonard Berger, the Gateposts Foundation, and the John Merck Fund.

PY - 1987/6/1

Y1 - 1987/6/1

N2 - Within- and across-day stability of plasma-free homovanillic acid (pHVA) was assessed in children and adults with Tourette's syndrome. A diurnal fall in pHVA was observed in 13 of 15 subjects. There was a small but significant (p < .0001) decrease (8%) in mean morning pHVA levels obtained just 20 minutes apart (8:30 A.M. and 8:50 A.M.). A substantial and significant (p < .001) mean decrease in pHVA (25%) was observed when samples obtained between 8:00 and 8:30 A.M. were compared with samples obtained at 12:00 noon. Changes in pHVA levels observed during the afternoon (between 12:00 noon and 4:00 P.M.) were small, nondirectional, and nonsignificant. Repeated measurement of morning pHVA in the same individual after 24 or more hours revealed marked increases or decreases in many individuals, suggesting that morning pHVA is not a stable measure. The results of this and previous studies suggest that pHVA obtained at 12:00 noon or later in the day may be a more reliable measure of centrally produced HVA. Further studies are needed regarding the stability of pHVA over time.

AB - Within- and across-day stability of plasma-free homovanillic acid (pHVA) was assessed in children and adults with Tourette's syndrome. A diurnal fall in pHVA was observed in 13 of 15 subjects. There was a small but significant (p < .0001) decrease (8%) in mean morning pHVA levels obtained just 20 minutes apart (8:30 A.M. and 8:50 A.M.). A substantial and significant (p < .001) mean decrease in pHVA (25%) was observed when samples obtained between 8:00 and 8:30 A.M. were compared with samples obtained at 12:00 noon. Changes in pHVA levels observed during the afternoon (between 12:00 noon and 4:00 P.M.) were small, nondirectional, and nonsignificant. Repeated measurement of morning pHVA in the same individual after 24 or more hours revealed marked increases or decreases in many individuals, suggesting that morning pHVA is not a stable measure. The results of this and previous studies suggest that pHVA obtained at 12:00 noon or later in the day may be a more reliable measure of centrally produced HVA. Further studies are needed regarding the stability of pHVA over time.

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ER -

Plasma-free homovanillic acid: Within- and across-day stability in children and adults with tourette's syndrome

Abstract

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