Plasma-free fatty acids, fatty acidebinding protein 4, and mortality in older adults (from the cardiovascular health study)

Michael D. Miedema, Marlena Maziarz, Mary L. Biggs, Susan J. Zieman, Jorge R. Kizer, Joachim H. Ix, Dariush Mozaffarian, Russell P. Tracy, Bruce M. Psaty, David S. Siscovick, Kenneth J. Mukamal, Luc Djousse

Research output: Contribution to journalArticle

Abstract

Plasma-free fatty acids (FFAs) are largely derived from adipose tissue. Elevated levels of FFA and fatty acidebinding protein 4 (FABP4), a key cytoplasmic chaperone of fatty acids, have been associated with adverse cardiovascular outcomes, but limited data are available on the relation of these biomarkers with cardiovascular and total mortality. We studied 4,707 participants with a mean age of 75 years who had plasma FFA and FABP4 measured in 1992 to 1993 as part of the Cardiovascular Health Study, an observational cohort of community-dwelling older adults. Over a median follow-up of 11.8 years, 3,555 participants died. Cox proportional hazard regression was used to determine the association between FFA, FABP4, and mortality. In fully adjusted models, FFA were associated with dosedependent significantly higher total mortality (hazard ratio [HR] per SD: 1.14, 95% confidence interval [CI] 1.09 to 1.18), but FABP4 levels were not (HR 1.04, 95% CI 0.98 to 1.09). In a cause-specific mortality analysis, higher concentrations of FFA were associated with significantly higher risk of death because of cardiovascular disease, dementia, infection, and respiratory causes but not cancer or trauma. We did not find evidence of an interaction between FFA and FABP4 (p[0.45), but FABP4 appeared to be associated with total mortality differentially in men and women (HR 1.17, 95% CI 1.08 to 1.26 for men; HR 1.02, 95% CI 0.96 to 1.07 for women, interaction p value

Original languageEnglish (US)
Pages (from-to)843-848
Number of pages6
JournalThe American Journal of Cardiology
Volume114
Issue number6
DOIs
StatePublished - 2015
Externally publishedYes

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Nonesterified Fatty Acids
Mortality
Health
Proteins
Confidence Intervals
Independent Living
Respiratory Tract Infections
Observational Studies
Dementia
Adipose Tissue
Cohort Studies
Cardiovascular Diseases
Fatty Acids
Biomarkers
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plasma-free fatty acids, fatty acidebinding protein 4, and mortality in older adults (from the cardiovascular health study). / Miedema, Michael D.; Maziarz, Marlena; Biggs, Mary L.; Zieman, Susan J.; Kizer, Jorge R.; Ix, Joachim H.; Mozaffarian, Dariush; Tracy, Russell P.; Psaty, Bruce M.; Siscovick, David S.; Mukamal, Kenneth J.; Djousse, Luc.

In: The American Journal of Cardiology, Vol. 114, No. 6, 2015, p. 843-848.

Research output: Contribution to journalArticle

Miedema, MD, Maziarz, M, Biggs, ML, Zieman, SJ, Kizer, JR, Ix, JH, Mozaffarian, D, Tracy, RP, Psaty, BM, Siscovick, DS, Mukamal, KJ & Djousse, L 2015, 'Plasma-free fatty acids, fatty acidebinding protein 4, and mortality in older adults (from the cardiovascular health study)', The American Journal of Cardiology, vol. 114, no. 6, pp. 843-848. https://doi.org/10.1016/j.amjcard.2014.06.012
Miedema, Michael D. ; Maziarz, Marlena ; Biggs, Mary L. ; Zieman, Susan J. ; Kizer, Jorge R. ; Ix, Joachim H. ; Mozaffarian, Dariush ; Tracy, Russell P. ; Psaty, Bruce M. ; Siscovick, David S. ; Mukamal, Kenneth J. ; Djousse, Luc. / Plasma-free fatty acids, fatty acidebinding protein 4, and mortality in older adults (from the cardiovascular health study). In: The American Journal of Cardiology. 2015 ; Vol. 114, No. 6. pp. 843-848.
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