TY - JOUR
T1 - Plasma Fractionation in the United States
T2 - A Review for Clinicians
AU - Ness, Paul M.
AU - Pennington, Robert M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1974/10/14
Y1 - 1974/10/14
N2 - The Cohn cold ethanol plasma fractionation system, developed in the late 1940s, is still the basis for plasma fractionation practices in the United States today. Plasma is obtained by plasmapheresis, salvaged from fresh or outdated whole blood, or is extracted from human placentas to produce five types of clinical products of proven efficacy and safety. Despite the recognized advantages and current entrenchment of the Cohn fractionation system and its partial solution of the hepatitis problem, new developments could improve the present practice. Improved salvage of useful proteins from fractions that are currently discarded must be strongly supported.
AB - The Cohn cold ethanol plasma fractionation system, developed in the late 1940s, is still the basis for plasma fractionation practices in the United States today. Plasma is obtained by plasmapheresis, salvaged from fresh or outdated whole blood, or is extracted from human placentas to produce five types of clinical products of proven efficacy and safety. Despite the recognized advantages and current entrenchment of the Cohn fractionation system and its partial solution of the hepatitis problem, new developments could improve the present practice. Improved salvage of useful proteins from fractions that are currently discarded must be strongly supported.
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U2 - 10.1001/jama.1974.03240020037020
DO - 10.1001/jama.1974.03240020037020
M3 - Article
C2 - 4137885
AN - SCOPUS:0016295102
SN - 0098-7484
VL - 230
SP - 247
EP - 250
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 2
ER -