Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography

D. M. Herrington, G. B. Gordon, Stephen C Achuff, J. F. Trejo, H. F. Weisman, P. O. Kwiterovich, T. A. Pearson

Research output: Contribution to journalArticle

Abstract

Serum levels of DHEA sulfate are inversely associated with cardiovascular death in men, and urinary dehydroepiandrosterone (DHEA) levels are inversely associated with clinical manifestations of coronary artery disease. These observations may be related to the antiproliferative effects of DHEA, resulting in inhibition of atherosclerotic intimal hyperplasia. To examine the relation between these steroids and a direct measure of coronary atherosclerosis, plasma DHEA and DHEA sulfate levels were determined in 206 middle-aged patients (103 men, 103 women) undergoing elective coronary angiography. Plasma DHEA sulfate levels were lower in men with at least one stenosis ≥ 50% compared with those without any stenosis ≥ 50% (4.9 ± 2.7 versus 6.1 ± 3.5 nmol/ml, p = 0.05). Levels of DHEA sulfate were also inversely related to the number of diseased coronary vessels (r = -0.20, p = 0.05) and a continuous measure of the extent of coronary atherosclerosis (r = -0.25, p = 0.01) in men. The association between DHEA sulfate levels and extent of coronary artery disease was independent of age and other conventional risk factors for coronary disease. In women, there was no association between plasma DHEA or DHEA sufate levels and coronary disease. These data demonstrate a consistent, independent, inverse, dose-response relation between plasma DHEA sulfate levels and angiographically defined coronary atherosclerosis in men. Plasma DHEA sulfate may be another important and potentially modifiable risk factor for the development and progression of coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)862-870
Number of pages9
JournalJournal of the American College of Cardiology
Volume16
Issue number4
StatePublished - 1990

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Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Coronary Angiography
Coronary Artery Disease
Coronary Disease
Pathologic Constriction
Tunica Intima
Hyperplasia
Coronary Vessels
Steroids
Serum

ASJC Scopus subject areas

  • Nursing(all)

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Herrington, D. M., Gordon, G. B., Achuff, S. C., Trejo, J. F., Weisman, H. F., Kwiterovich, P. O., & Pearson, T. A. (1990). Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. Journal of the American College of Cardiology, 16(4), 862-870.

Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. / Herrington, D. M.; Gordon, G. B.; Achuff, Stephen C; Trejo, J. F.; Weisman, H. F.; Kwiterovich, P. O.; Pearson, T. A.

In: Journal of the American College of Cardiology, Vol. 16, No. 4, 1990, p. 862-870.

Research output: Contribution to journalArticle

Herrington, DM, Gordon, GB, Achuff, SC, Trejo, JF, Weisman, HF, Kwiterovich, PO & Pearson, TA 1990, 'Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography', Journal of the American College of Cardiology, vol. 16, no. 4, pp. 862-870.
Herrington, D. M. ; Gordon, G. B. ; Achuff, Stephen C ; Trejo, J. F. ; Weisman, H. F. ; Kwiterovich, P. O. ; Pearson, T. A. / Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. In: Journal of the American College of Cardiology. 1990 ; Vol. 16, No. 4. pp. 862-870.
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