Plasma cytokines and chemokines in Zambian children with measles: Innate responses and association with HIV-1 coinfection and in-hospital mortality

Wen Hsuan W. Lin, Ashley N. Nelson, Judith J. Ryon, William J. Moss, Diane E. Griffin

Research output: Contribution to journalArticle

Abstract

To identify immune factors present during the acute rash phase of measles and associations with outcome and human immunodeficiency virus type 1 (HIV-1) coinfection, we measured the plasma levels of 22 cytokines and chemokines in Zambian children hospitalized with measles (n = 148) and control children (n = 44). Children with measles had higher levels of innate cytokines tumor necrosis factor (TNF) α, interleukin 1β (IL-1β), interleukin 18, and interleukin 6; chemokines CCL2, CCL4, CCL11, CCL22, CXCL8, and CXCL10; and T-cell cytokines interferon γ, and interleukin 2, 10, and 17. Children who died in the hospital had higher levels of TNF-α, IL-1β, interleukin 12p70; CCL2, CCL4, CCL13, CCL17, CXCL8, CXCL10; and interleukin 2 and interferon γ than children who survived, and lower levels of interleukin 4. Children coinfected with HIV-1 had higher levels of TNF-α and IL-1β than HIVuninfected children with measles, and lower levels of interleukin 4 and 5. Therefore, acute measles was characterized by activation of macrophages and T cells producing type 1, but not type 2, cytokines, which was more pronounced in fatal disease.

Original languageEnglish (US)
Pages (from-to)830-839
Number of pages10
JournalJournal of Infectious Diseases
Volume215
Issue number5
DOIs
StatePublished - 2017

Fingerprint

Measles
Hospital Mortality
Coinfection
Chemokines
HIV-1
Cytokines
Interleukin-1beta
Tumor Necrosis Factor-alpha
Interleukin-4
Interferon-gamma
Interleukin-2
T-Lymphocytes
Chemokine CCL4
Interleukin-18
Hospitalized Child
Macrophage Activation
Interleukin-17
Chemokine CCL2
Interleukins
Interleukin-5

Keywords

  • Inflammasome
  • Innate responses
  • Macrophage activation
  • Measles
  • NF-κB

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Plasma cytokines and chemokines in Zambian children with measles : Innate responses and association with HIV-1 coinfection and in-hospital mortality. / Lin, Wen Hsuan W.; Nelson, Ashley N.; Ryon, Judith J.; Moss, William J.; Griffin, Diane E.

In: Journal of Infectious Diseases, Vol. 215, No. 5, 2017, p. 830-839.

Research output: Contribution to journalArticle

Lin, Wen Hsuan W.; Nelson, Ashley N.; Ryon, Judith J.; Moss, William J.; Griffin, Diane E. / Plasma cytokines and chemokines in Zambian children with measles : Innate responses and association with HIV-1 coinfection and in-hospital mortality.

In: Journal of Infectious Diseases, Vol. 215, No. 5, 2017, p. 830-839.

Research output: Contribution to journalArticle

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