Plasma concentrations of carminomycin and carminomycinol in man, measured by high pressure liquid chromatography

J. Lankelma, P. G M Penders, J. G. McVie, A. Leyva, W. W. Ten Bokkel-Huinink, M. M. De Planque, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

In 9 patients with advanced malignant disease who received carminomycin (CMM) in an i.v. bolus injection (dose 18 mg/m2), curves of plasma concentrations of CMM and carminomycinol (CMMOH), a metabolite, versus time were constructed. For determination of plasma concentrations, high pressure liquid chromatography was used. For CMM and CMMOH the median areas under the curves (AUC's) were 31 (range 4-57) × 10-8 mol/l/hr (measured over 24 hr) and 100 (range 30-158) × 10-8 mol/l/hr (measured over 48 hr) respectively. From the data an accumulation of CMMOH in patients receiving treatments separated by brief intervals can be predicted (half-life time of plasma disappearance for CMMOH was 2 days). Clinical toxicity was lowest in those 3 patients showing the lowest AUC for both CMM and CMMOH.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalEuropean Journal of Cancer and Clinical Oncology
Volume18
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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