Plasma clearance rates of coagulation factors VIII and IX in factor-deficient individuals

D. A. Noe, W. R. Bell, P. M. Ness, J. Levin

Research output: Contribution to journalArticle

Abstract

The plasma clearance rates of factors IX and VIII were determined in patients with hemophilia A and B who had received factor replacement by prolonged, continuous infusion of factor concentrates. The clearance rates were calculated by dividing the factor infusion rates by the steady-state plasma factor activities corrected for baseline factor activities. The mean factor IX clearance rate in eight factor IX-deficient patients was 233 mL/h (range 159 to 340 mL/h). The mean normalized clearance rate was 3.4 mL/h/kg. The mean factor VIII clearance rate in eight factor VIII-deficient patients was 294 mL/h (range 229 to 361 mL/h) and the mean normalized rate was 5.0 mL/h/kg. Both factors show linear relationships between the factor infusion rates and the steady-state plasma factor activities achieved.

Original languageEnglish (US)
Pages (from-to)969-972
Number of pages4
JournalBlood
Volume67
Issue number4
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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