## Abstract

The plasma clearance rates of factors IX and VIII were determined in patients with hemophilia A and B who had received factor replacement by prolonged, continuous infusion of factor concentrates. The clearance rates were calculated by dividing the factor infusion rates by the steady-state plasma factor activities corrected for baseline factor activities. The mean factor IX clearance rate in eight factor IX-deficient patients was 233 mL/h (range 159 to 340 mL/h). The mean normalized clearance rate was 3.4 mL/h/kg. The mean factor VIII clearance rate in eight factor VIII-deficient patients was 294 mL/h (range 229 to 361 mL/h) and the mean normalized rate was 5.0 mL/h/kg. Both factors show linear relationships between the factor infusion rates and the steady-state plasma factor activities achieved.

Original language | English (US) |
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Pages (from-to) | 969-972 |

Number of pages | 4 |

Journal | Blood |

Volume | 67 |

Issue number | 4 |

DOIs | |

State | Published - 1986 |

## ASJC Scopus subject areas

- Biochemistry
- Immunology
- Hematology
- Cell Biology