Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy

Ting Ting Hong, Rebecca Cogswell, Cynthia Anne James, Guson Kang, Clive R. Pullinger, Mary J. Malloy, John P. Kane, Julianne Wojciak, Hugh Calkins, Melvin M. Scheinman, Zian H. Tseng, Peter Ganz, Teresa De Marco, Daniel P. Judge, Robin M. Shaw

Research output: Contribution to journalArticle

Abstract

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder involving diseased cardiac muscle. Bridging integrator 1 (BIN1) is a membrane-associated protein important to cardiomyocyte homeostasis and is downregulated in cardiomyopathy. We hypothesized that BIN1 could be released into the circulation and that blood-available BIN1 can provide useful data on the cardiac status of patients whose hearts are failing secondary to ARVC. Objective: To determine whether plasma BIN1 levels can be used to measure disease severity in patients with ARVC. Methods: We performed a retrospective cohort study of 24 patients with ARVC. Plasma BIN1 levels were assessed for their ability to correlate with cardiac functional status and predict ventricular arrhythmias. Results: Mean plasma BIN1 levels were decreased in patients with ARVC with heart failure (15 ± 7 vs 60 ± 17 in patients without heart failure, P

Original languageEnglish (US)
Pages (from-to)961-967
Number of pages7
JournalHeart Rhythm
Volume9
Issue number6
DOIs
StatePublished - Jun 2012

    Fingerprint

Keywords

  • Arrhythmogenic right ventricular cardiomyopathy
  • BIN1
  • Bridging integrator 1
  • Calcium transient
  • Heart failure
  • Membrane adaptor protein
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hong, T. T., Cogswell, R., James, C. A., Kang, G., Pullinger, C. R., Malloy, M. J., Kane, J. P., Wojciak, J., Calkins, H., Scheinman, M. M., Tseng, Z. H., Ganz, P., De Marco, T., Judge, D. P., & Shaw, R. M. (2012). Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm, 9(6), 961-967. https://doi.org/10.1016/j.hrthm.2012.01.024