Plasma beta amyloid level and depression in older adults

Andrea L. Metti, Jane A. Cauley, Anne B. Newman, Hilsa N. Ayonayon, Lisa C. Barry, Lewis M. Kuller, Suzanne Satterfield, Eleanor M. Simonsick, Kristine Yaffe

Research output: Contribution to journalArticle

Abstract

Background.Older adults with depression have an increased risk of developing dementia. Low plasma beta-amyloid 42 (Aβ42) and Aβ42/Aβ40 have emerged as promising biomarkers of dementia. The association between depression and plasma Aβ is unclear.Methods.In this longitudinal study of 988 community-dwelling elders from the Health Aging and Body Composition study, depression was assessed with the Center for Epidemiologic Studies-Depression Scale 10-item version. We determined the association between Aβ42 and Aβ42/Aβ40 tertile and depression at baseline and over 9 years. We also stratified the models to determine if apolipoprotein E e4 allele status modified the associations.Results.Mean baseline age was 74.0 ± 3.0 years, 51 (5.2%) participants had depression, 545 (55.2%) were women, 531 (53.7%) were black, and 286 (30.7%) had one or more apolipoprotein E e4 allele. At baseline, there was no association between Aβ42/Aβ40 or Aβ42 and depression. Over 9 years, 220 (23.5%) participants developed depression. In adjusted Cox proportional hazards models, among those with one or more e4 allele, low Aβ42/Aβ40 was associated with an increased risk of developing depression over time (low 10.8% vs high 3.2%, hazard ratio = 2.38, 95% confidence interval: 1.15-4.92). Among those with no e4 allele, there was no association between Aβ42/Aβ40 and risk of depression over time (13.3% vs 17.5%, hazard ratio = 0.80, 95% confidence interval: 0.52-1.23; p value for interaction =. 003).Conclusions.The association between low plasma Aβ42/Aβ40 and increased risk of incident depression among those with one or more apolipoprotein E e4 allele implies a synergistic relationship similar to that found with dementia. Future work should investigate the interrelationships among plasma Aβ42/Aβ40, depression, and dementia.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2013

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Keywords

  • Depression
  • Epidemiology
  • Plasma beta amyloid

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Metti, A. L., Cauley, J. A., Newman, A. B., Ayonayon, H. N., Barry, L. C., Kuller, L. M., Satterfield, S., Simonsick, E. M., & Yaffe, K. (2013). Plasma beta amyloid level and depression in older adults. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68(1), 74-79. https://doi.org/10.1093/gerona/gls093