Plasma amino acid concentrations in healthy elderly men and women

B. Caballero, R. E. Gleason, R. J. Wurtman

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Postabsorptive plasma concentrations of the large neutral amino acids (LNAAs) were measured in 74 elderly (age 71 ± 8 y) and 138 young (age 26 ± 5 y) healthy subjects. Plasma concentrations of valine, leucine, and isoleucine were significantly lower in young females than in young males. This gender-related difference was not observed among elderly subjects because aging was associated with a significant rise in plasma LNAAs in females but not in males. Multiple-regression analysis of plasma amino acid concentrations from female subjects revealed a significant and positive effect of age on plasma valine, leucine, isoleucine, phenylalanine, and tyrosine but not on plasma tryptophan or methionine. Tryptophan was the only amino acid to exhibit a significant response to age in males, consisting of a 14% decline in the elderly subjects. Percentile ranges are presented for young and elderly females and males for each of the amino acids.

Original languageEnglish (US)
Pages (from-to)1249-1252
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number5
StatePublished - 1991


  • Aging
  • Normal values
  • Plasma amino acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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