Plasma amine metabolites before and after withdrawal from neuroleptic treatment in chronic schizophrenic inpatients

Darrell G. Kirch; George Jaskiw; Markku Linnoila; Daniel R. Weinberger; Richard J. Wyatt

doi:10.1016/0165-1781(88)90094-7

Plasma amine metabolites before and after withdrawal from neuroleptic treatment in chronic schizophrenic inpatients

Darrell G. Kirch, George Jaskiw, Markku Linnoila, Daniel R. Weinberger, Richard J. Wyatt

Research output: Contribution to journal › Article › peer-review

Abstract

Plasma catecholamine metabolites were measured in paired blood samples from 22 subjects with chronic schizophrenia. One sample was drawn while patients were on a stable dose of neuroleptic medication; the second was drawn 6 weeks after discontinuation of medication. In comparison with baseline values during neuroleptic treatment, there was a significant increase in the plasma concentration of the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), and a trend toward an increase in the plasma concentration of the dopamine metabolite, homovanillic acid (HVA), in the medication-free subjects. There were no significant correlations between plasma MHPG or HVA concentrations and the corresponding ratings of psychopathology for these patients.

Original language	English (US)
Pages (from-to)	233-242
Number of pages	10
Journal	Psychiatry research
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(88)90094-7
State	Published - Sep 1988
Externally published	Yes

Keywords

3-methoxy-4-hydroxyphenylglycol
Schizophrenia
homovanillic acid
tardive dyskinesia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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AU - Wyatt, Richard J.

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