Plasma amine metabolites before and after withdrawal from neuroleptic treatment in chronic schizophrenic inpatients

Darrell G. Kirch, George Jaskiw, Markku Linnoila, Daniel R. Weinberger, Richard J. Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma catecholamine metabolites were measured in paired blood samples from 22 subjects with chronic schizophrenia. One sample was drawn while patients were on a stable dose of neuroleptic medication; the second was drawn 6 weeks after discontinuation of medication. In comparison with baseline values during neuroleptic treatment, there was a significant increase in the plasma concentration of the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), and a trend toward an increase in the plasma concentration of the dopamine metabolite, homovanillic acid (HVA), in the medication-free subjects. There were no significant correlations between plasma MHPG or HVA concentrations and the corresponding ratings of psychopathology for these patients.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalPsychiatry research
Volume25
Issue number3
DOIs
StatePublished - Sep 1988
Externally publishedYes

Keywords

  • 3-methoxy-4-hydroxyphenylglycol
  • Schizophrenia
  • homovanillic acid
  • tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Plasma amine metabolites before and after withdrawal from neuroleptic treatment in chronic schizophrenic inpatients'. Together they form a unique fingerprint.

Cite this