Plasma adrenocorticotropin responses to opioid blockade with naloxone: Generating a dose-response curve in a single session

Deborah Mangold, Mary Elizabeth McCaul, Mahmood Ali, Gary Steven Wand

Research output: Contribution to journalArticlepeer-review

Abstract

We examined two methods of generating a dose-response curve to the opioid receptor antagonist naloxone. In 15 healthy male subjects (18-25 years) plasma adrenocorticotropin (ACTH) responses to five doses of naloxone studied over 5 separate days were compared to plasma ACTH responses to five incremental doses of naloxone studied within a single session. There was a statistically significant positive correlation in ACTH responses (area under the curve and peak) between dosing methods. Furthermore, the doses of naloxone that produced half-maximal and maximal ACTH response were similar. The comparability of ACTH responses between the two naloxone dosing techniques, combined with the safety and ease associated with the single- session methodology, underscores the usefulness of the single-session technique for future investigations. (C) 2000 Society of Biological Psychiatry.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalBiological psychiatry
Volume48
Issue number4
DOIs
StatePublished - Aug 15 2000

Keywords

  • Adrenocorticotropin
  • Dose-response curve
  • Hormones
  • Naloxone
  • Neuroendocrine
  • Opioid receptor blockade

ASJC Scopus subject areas

  • Biological Psychiatry

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