Plasma 25-hydroxyvitamin D concentrations and risk of incident cancer in adults with hypertension: A nested case–control study

Tengfei Lin, Yun Song, Xianglin Zhang, Huiyuan Guo, Lishun Liu, Ziyi Zhou, Binyan Wang, Genfu Tang, Chengzhang Liu, Yan Yang, Wenhua Ling, Zhengqiang Yuan, Jianping Li, Yan Zhang, Yong Huo, Xiaobin Wang, Hao Zhang, Xianhui Qin, Xiping Xu

Research output: Contribution to journalArticlepeer-review


Background & aims: Evidence from epidemiologic studies on the association of circulating 25-hydroxyvitamin D [25(OH)D] concentrations with the incident risk of cancer has been inconsistent. We aimed to investigate the prospective relationship of baseline plasma 25(OH)D concentrations with the risk of cancer, and to examine possible effect modifiers. Methods: We employed a nested case–control study design, including 231 patients with incident cancer during a median 4.5 years of follow up, and 231 matched controls from the China Stroke Primary Prevention Trial (CSPPT). Results: The prevalence of plasma 25(OH)D <15, <20 and <30 ng/mL was 23.6%, 47.4% and 85.5%, respectively. Overall, there was an inverse relation between risk of cancer and plasma 25(OH)D. The Odds ratios (95% CI) for participants in the second (15.1 to <20.6 ng/mL), third (20.6 to <26.4 ng/mL) and fourth quartiles (≥26.4 ng/mL) were 0.45 (95% CI: 0.25–0.80), 0.53 (95% CI: 0.27–1.06) and 0.55 (95% CI: 0.27–1.10), respectively, compared with those in quartile 1. Conversely, low 25(OH)D (<15.1 ng/mL) concentrations were associated with increased risk of cancer (OR, 2.08; 95% CI: 1.20–3.59) compared to higher concentrations. These associations were consistent across subtypes of cancer. Several potential effect modifiers were identified, including plasma vitamin E concentrations and alcohol intake. Conclusions: Low plasma 25(OH)D concentrations (<15.1 ng/mL) were associated with increased total cancer risk among Chinese hypertensive adults, compared to higher 25(OH)D concentrations. This finding and the possible effect modifiers warrant additional investigation.

Original languageEnglish (US)
Pages (from-to)2381-2388
Number of pages8
JournalClinical Nutrition
Issue number5
StatePublished - Oct 2019


  • 25-Hydroxyvitamin D
  • Alcohol intake
  • Cancer incidence
  • Folate
  • Vitamin E

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine


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