Plasma 17-hydroxycorticosteroids in hyperfunction, suppression, and deficiency of adrenal cortical function

Avery A. Sandberg, Kristen Eik-Nes, Claude J. Migeon, George F. Koepf

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma 17-OHCS levels and adrenocortical capacity were greatly reduced in most patients on long-term steroid (cortisol, cortisone) therapy. In some subjects, however, the adrenal cortex showed remarkable ability in returning to normal function after abrupt cessation of steroid therapy. The rate of metabolism of intravenously administered cortisol was essentially normal in subjects following abrupt cessation of prolonged steroid therapy, although the plasma 17-OHCS concentrations tended to be higher in 2 of the patients. Four of 12 patients with Addison's disease had low levels of 17-OHCS during ACTH infusion. Two of 3 patients with Cushing's syndrome due to adrenocortical hyperplasia showed exaggerated plasma 17-OHCS levels during ACTH infusion, while the third patient had a fairly normal response. A patient with functioning carcinoma of the adrenal showed elevated 17-OHCS levels with no changes during ACTH infusion.

Original languageEnglish (US)
Pages (from-to)286-296
Number of pages11
JournalThe Journal of laboratory and clinical medicine
Volume50
Issue number2
StatePublished - Aug 1 1957

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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