Plant derived therapeutics for the treatment of Leishmaniasis

Rupashree Sen; Mitali Chatterjee

doi:10.1016/j.phymed.2011.03.004

Plant derived therapeutics for the treatment of Leishmaniasis

Rupashree Sen, Mitali Chatterjee

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Abstract

Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a neglected public health problem. Leishmania, a unicellular protozoan parasite is the causative organism of Leishmaniasis and is transmitted by female phlebotamine sandflies affecting millions of people worldwide. In the wake of resistance to pentavalent antimonial drugs, new therapeutic alternatives are desirable. The plant kingdom has in the past provided several affordable compounds and this review aims to provide an overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells. Furthermore, delineation of the contributory biochemical mechanisms involved in mediating their effect would help develop new chemotherapeutic approaches.

Original language	English (US)
Pages (from-to)	1056-1069
Number of pages	14
Journal	Phytomedicine
Volume	18
Issue number	12
DOIs	https://doi.org/10.1016/j.phymed.2011.03.004
State	Published - Sep 15 2011
Externally published	Yes

Keywords

Amastigotes
Antileishmanial
Plant derived compounds

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1016/j.phymed.2011.03.004

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title = "Plant derived therapeutics for the treatment of Leishmaniasis",

abstract = "Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a neglected public health problem. Leishmania, a unicellular protozoan parasite is the causative organism of Leishmaniasis and is transmitted by female phlebotamine sandflies affecting millions of people worldwide. In the wake of resistance to pentavalent antimonial drugs, new therapeutic alternatives are desirable. The plant kingdom has in the past provided several affordable compounds and this review aims to provide an overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells. Furthermore, delineation of the contributory biochemical mechanisms involved in mediating their effect would help develop new chemotherapeutic approaches.",

keywords = "Amastigotes, Antileishmanial, Plant derived compounds",

author = "Rupashree Sen and Mitali Chatterjee",

note = "Funding Information: RS is the recipient of a Senior Research Fellowship from Indian Council of Medical Research, Govt. of India. This work received financial assistance from Indian Council of Medical Research (ICMR), Council for Scientific and Industrial Research (CSIR) and Dept. of Science and Technology (DST), Govt. of India. ",

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AU - Chatterjee, Mitali

N1 - Funding Information: RS is the recipient of a Senior Research Fellowship from Indian Council of Medical Research, Govt. of India. This work received financial assistance from Indian Council of Medical Research (ICMR), Council for Scientific and Industrial Research (CSIR) and Dept. of Science and Technology (DST), Govt. of India.

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N2 - Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a neglected public health problem. Leishmania, a unicellular protozoan parasite is the causative organism of Leishmaniasis and is transmitted by female phlebotamine sandflies affecting millions of people worldwide. In the wake of resistance to pentavalent antimonial drugs, new therapeutic alternatives are desirable. The plant kingdom has in the past provided several affordable compounds and this review aims to provide an overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells. Furthermore, delineation of the contributory biochemical mechanisms involved in mediating their effect would help develop new chemotherapeutic approaches.

AB - Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a neglected public health problem. Leishmania, a unicellular protozoan parasite is the causative organism of Leishmaniasis and is transmitted by female phlebotamine sandflies affecting millions of people worldwide. In the wake of resistance to pentavalent antimonial drugs, new therapeutic alternatives are desirable. The plant kingdom has in the past provided several affordable compounds and this review aims to provide an overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells. Furthermore, delineation of the contributory biochemical mechanisms involved in mediating their effect would help develop new chemotherapeutic approaches.

KW - Amastigotes

KW - Antileishmanial

KW - Plant derived compounds

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Plant derived therapeutics for the treatment of Leishmaniasis

Abstract

Keywords

ASJC Scopus subject areas

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