Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents

Bridget E. Young, Elizabeth M. Cooper, Allison W. McIntyre, Tera Kent, Frank Witter, Z. Leah Harris, Kimberly O. O'Brien

Research output: Contribution to journalArticle

Abstract

The purpose of the study was to identify determinants of placental vitamin D receptor (VDR) expression and placental calcium (Ca) transfer among pregnant adolescents. Placental tissue was obtained in 94 adolescents (≥18 yr) at term. In 12 of these teens, stable Ca isotopes were given intravenously ( 42Ca) and orally (44Ca) early in labor. Placental VDR expression was assessed via Western blot and validated by RTPCR. Maternal-to-fetal Ca transfer was calculated as the enrichment in cord blood at delivery relative to maternal serum enrichment 2 h postdosing. Isotopic study outcomes were examined in relation to fetal long bone length, placental VDR, serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) 2D], and parathyroid hormone (PTH) in maternal circulation and cord blood at delivery. Placental VDR expression was inversely associated with neonatal 25(OH)D (P=0.012) and positively with neonatal 1,25(OH)2D (P=0.006). Placental VDR was a positive predictor of fetal femur length Z score (P=0.018; R2=0.06) and was positively correlated with maternal-to-fetal transfer of intravenous 42Ca (P=0.004; R2=0.62). The fetus may regulate placental VDR expression given the significant associations with neonatal vitamin D metabolites. The association between placental VDR and fetal long bone length may indicate a role for VDR in fetal bone development, potentially by mediating transplacental Ca transfer.

Original languageEnglish (US)
Pages (from-to)2029-2037
Number of pages9
JournalFASEB Journal
Volume28
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • 1,25(OH)2D
  • 25(OH)D
  • Calcidiol
  • Gestation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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