Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda

Fred Wabwire-Mangen, Ronald H Gray, Francis A. Mmiro, Christopher Ndugwa, Carlos Abramowsky, Henry Wabinga, Christopher Whalen, Chuanjun Li, Alfred J. Saah

Research output: Contribution to journalArticle

Abstract

Prospective follow-up of 172 HIV-infected pregnant women and their infants was conducted at Mulago Hospital, Kampala, Uganda during 1990 to 1992. Information was collected on maternal immune status (CD4 counts or clinical AIDS), and concurrent infections with sexually transmitted diseases. Infants were observed on a follow-up basis to determine HIV infection, using polymerase chain reaction (PCR) under 15 months of age and enzyme immunoassay/Western blot for those older than 15 months. Placental membrane inflammation (chorioamnionitis and funisitis), and placental villous inflammation (villitis, intervillitis, and deciduitis) were diagnosed by histopathology. Mother-to-child HIV transmission rates were assessed, and adjusted odds ratios (OR) and 95% confidence intervals (95% CI) of transmission were estimated using women with no placental pathology or evidence of immune suppression as a reference group. Results: The overall mother-to-child HIV transmission rate was 23.3%. Women with no placental membrane inflammation or immune suppression had a transmission rate of 11.3%; compared with 25.5% in women with placental inflammation and no immunosuppression (adjusted OR, 2.87; 95% CI, 1.04-7.90), and 37.0% in immunosuppressed women (OR, 3.07; 95% CI, 1.42-6.67). We estimate that 34% of HIV transmission could be prevented by treatment of placental membrane inflammation in nonimmunocompromised women. Transmission rates were 40.9% with genital ulcer disease (OR, 3.57; 95% CI, 1.28-9.66). Placental villous inflammation and artificial rapture of membranes did not increase transmission rates and cesarean section was associated with a nonsignificant reduction of risk (OR, 0.70; 95% CI 0.24-2.06). Conclusion: Placental membrane inflammation increases the rate of mother-to-child HIV transmission.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume22
Issue number4
StatePublished - Dec 1 1999

Fingerprint

Uganda
HIV-1
Mothers
Inflammation
Odds Ratio
Membranes
HIV
Confidence Intervals
Chorioamnionitis
Artificial Membranes
CD4 Lymphocyte Count
Sexually Transmitted Diseases
Immunoenzyme Techniques
Cesarean Section
Immunosuppression
Ulcer
HIV Infections
Pregnant Women
Acquired Immunodeficiency Syndrome
Western Blotting

Keywords

  • Chorioamnionitis
  • Mother-to-child HIV transmission
  • Placental membrane inflammation
  • Uganda

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Wabwire-Mangen, F., Gray, R. H., Mmiro, F. A., Ndugwa, C., Abramowsky, C., Wabinga, H., ... Saah, A. J. (1999). Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 22(4), 379-385.

Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda. / Wabwire-Mangen, Fred; Gray, Ronald H; Mmiro, Francis A.; Ndugwa, Christopher; Abramowsky, Carlos; Wabinga, Henry; Whalen, Christopher; Li, Chuanjun; Saah, Alfred J.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 22, No. 4, 01.12.1999, p. 379-385.

Research output: Contribution to journalArticle

Wabwire-Mangen, F, Gray, RH, Mmiro, FA, Ndugwa, C, Abramowsky, C, Wabinga, H, Whalen, C, Li, C & Saah, AJ 1999, 'Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 22, no. 4, pp. 379-385.
Wabwire-Mangen, Fred ; Gray, Ronald H ; Mmiro, Francis A. ; Ndugwa, Christopher ; Abramowsky, Carlos ; Wabinga, Henry ; Whalen, Christopher ; Li, Chuanjun ; Saah, Alfred J. / Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1999 ; Vol. 22, No. 4. pp. 379-385.
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abstract = "Prospective follow-up of 172 HIV-infected pregnant women and their infants was conducted at Mulago Hospital, Kampala, Uganda during 1990 to 1992. Information was collected on maternal immune status (CD4 counts or clinical AIDS), and concurrent infections with sexually transmitted diseases. Infants were observed on a follow-up basis to determine HIV infection, using polymerase chain reaction (PCR) under 15 months of age and enzyme immunoassay/Western blot for those older than 15 months. Placental membrane inflammation (chorioamnionitis and funisitis), and placental villous inflammation (villitis, intervillitis, and deciduitis) were diagnosed by histopathology. Mother-to-child HIV transmission rates were assessed, and adjusted odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI) of transmission were estimated using women with no placental pathology or evidence of immune suppression as a reference group. Results: The overall mother-to-child HIV transmission rate was 23.3{\%}. Women with no placental membrane inflammation or immune suppression had a transmission rate of 11.3{\%}; compared with 25.5{\%} in women with placental inflammation and no immunosuppression (adjusted OR, 2.87; 95{\%} CI, 1.04-7.90), and 37.0{\%} in immunosuppressed women (OR, 3.07; 95{\%} CI, 1.42-6.67). We estimate that 34{\%} of HIV transmission could be prevented by treatment of placental membrane inflammation in nonimmunocompromised women. Transmission rates were 40.9{\%} with genital ulcer disease (OR, 3.57; 95{\%} CI, 1.28-9.66). Placental villous inflammation and artificial rapture of membranes did not increase transmission rates and cesarean section was associated with a nonsignificant reduction of risk (OR, 0.70; 95{\%} CI 0.24-2.06). Conclusion: Placental membrane inflammation increases the rate of mother-to-child HIV transmission.",
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AB - Prospective follow-up of 172 HIV-infected pregnant women and their infants was conducted at Mulago Hospital, Kampala, Uganda during 1990 to 1992. Information was collected on maternal immune status (CD4 counts or clinical AIDS), and concurrent infections with sexually transmitted diseases. Infants were observed on a follow-up basis to determine HIV infection, using polymerase chain reaction (PCR) under 15 months of age and enzyme immunoassay/Western blot for those older than 15 months. Placental membrane inflammation (chorioamnionitis and funisitis), and placental villous inflammation (villitis, intervillitis, and deciduitis) were diagnosed by histopathology. Mother-to-child HIV transmission rates were assessed, and adjusted odds ratios (OR) and 95% confidence intervals (95% CI) of transmission were estimated using women with no placental pathology or evidence of immune suppression as a reference group. Results: The overall mother-to-child HIV transmission rate was 23.3%. Women with no placental membrane inflammation or immune suppression had a transmission rate of 11.3%; compared with 25.5% in women with placental inflammation and no immunosuppression (adjusted OR, 2.87; 95% CI, 1.04-7.90), and 37.0% in immunosuppressed women (OR, 3.07; 95% CI, 1.42-6.67). We estimate that 34% of HIV transmission could be prevented by treatment of placental membrane inflammation in nonimmunocompromised women. Transmission rates were 40.9% with genital ulcer disease (OR, 3.57; 95% CI, 1.28-9.66). Placental villous inflammation and artificial rapture of membranes did not increase transmission rates and cesarean section was associated with a nonsignificant reduction of risk (OR, 0.70; 95% CI 0.24-2.06). Conclusion: Placental membrane inflammation increases the rate of mother-to-child HIV transmission.

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