Placental malaria and mother-to-child transmission of human immunodeficiency virus-1

Gernard I. Msamanga, Taha E. Taha, Alicia M. Young, Elizabeth R. Brown, Irving F. Hoffman, Jennifer S. Read, Victor Mudenda, Robert L. Goldenberg, Usha Sharma, Moses Sinkala, Wafaie W. Fawzi

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Abstract

There are few studies of the association between placental malaria (PM) and mother-to-child transmission (MTCT) of human immunodeficiency virus-1 (HIV-1), and the results of published studies are inconsistent. To determine the association between PM and MTCT of HIV-1, we performed a secondary analysis of data from a clinical trial of antibiotics to reduce chorioamnionitis. Data regarding 1,662 HIV-l-infected women with live born singleton and first-born twin infants with information regarding PM and infant HIV-1 infection status at birth were analyzed. At the time of the study, women did not have access to antiretroviral drugs for treatment of acquired immunodeficiency syndrome but had received nevirapine prophylaxis to reduce the risk of MTCT of HIV-1. Placental malaria was not associated with the infant HIV-1 infection status at birth (P=0.67). Adjustment for maternal plasma viral load and CD4+ cell count did not change these results (odds ratio = 1.06,95% confidence interval = 0.51-2.20, P = 0.87). Placental malaria was more likely to be related to HIV-1 infection at birth among women with low viral load at baseline (P for interaction = 0.08). In conclusion, PM was not associated with infant HIV-1 infection status at birth. The interaction of maternal plasma viral load, PM, and MTCT of HIV-1 warrants further studies.

Original languageEnglish (US)
Pages (from-to)508-515
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume80
Issue number4
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Msamanga, G. I., Taha, T. E., Young, A. M., Brown, E. R., Hoffman, I. F., Read, J. S., Mudenda, V., Goldenberg, R. L., Sharma, U., Sinkala, M., & Fawzi, W. W. (2009). Placental malaria and mother-to-child transmission of human immunodeficiency virus-1. American Journal of Tropical Medicine and Hygiene, 80(4), 508-515.