Placental Cryptococcus neoformans infection without neonatal disease: Case report and review of the literature

Angela D. Darko, Daniel C. Dim, Gregory Taylor, Douglas C. Watson, Chen Chih Sun

Research output: Contribution to journalArticle

Abstract

We report placental cryptococcosis in a woman with multidrug resistant human immunodeficiency virus (HIV) infection. She received antifungal therapy for cryptococcal meningitis prior to delivery. Cesarean section was performed with delivery of a single full-term male infant. There was no evidence of HIV or cryptococcal infection in the infant. The placenta grossly showed multiple white nodules. Microscopically, numerous encapsulated budding yeasts, morphologically consistent with cryptococci, were identified in the intervillous space and, to a lesser extent, in the chorionic villi. Cryptococcal infections are not uncommon, but only 2 cases of placental cryptococcosis have been reported. Our case is the 1st account documenting cryptococcal organisms within the chorionic villi, and yet there was no evidence of infection in the infant. Mother-to-fetal transmission of cryptococcal infection is not well defined. We review the literature and discuss its possible mechanisms.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalPediatric and Developmental Pathology
Volume12
Issue number3
DOIs
StatePublished - May 1 2009

Keywords

  • Acquired immunodeficiency syndrome
  • Cryptococcus
  • Human immunodeficiency virus
  • Placenta

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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