Placental α-Microglobulin-1 in Vaginal Secretions of Women with Evidence of Preterm Labor

Robert M. Ehsanipoor, Morgan L. Swank, Seung Chik Jwa, Deborah A. Wing, Gofran Tarabulsi, Karin J. Blakemore

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To evaluate the presence of placental α-microglobulin-1 (PAMG-1) in vaginal secretions in women with symptoms of preterm labor and assess its use as a predictor of preterm birth. Study Design A prospective cohort study of women between 16 and 34 weeks of gestation with symptoms of preterm labor and intact membranes was conducted. The presence of PAMG-1 was determined using a commercially available kit (AmniSure, AmniSure International LLC, Boston, MA). Results A total of 100 women were enrolled, of which 86 had outcome data available. PAMG-1 was detected in 19/86 (22.1%) subjects. These women were more likely to deliver within 7 days than those without PAMG-1 detected (6/19 [31.6%] vs. 5/67 [7.5%]; odds ratio 5.6; 95% confidence interval 1.5-21.6). These findings persisted after adjusting for potential confounders. The sensitivity was 54.6%, specificity was 82.7%, positive predictive value was 31.6%, and the negative predictive was 92.5%. Conclusion The presence of PAMG-1 is associated with an increased likelihood of delivery within 7 days.

Original languageEnglish (US)
Pages (from-to)208-213
Number of pages6
JournalAmerican journal of perinatology
Volume33
Issue number2
DOIs
StatePublished - Sep 14 2015

Keywords

  • placental α-microglobulin-1
  • prematurity
  • preterm birth
  • preterm labor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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