Pivotal trials of cardiac resynchronization therapy: Evolution to therapy in mild heart failure

John Rickard, Bruce Larry Wilkoff

Research output: Contribution to journalArticle

Abstract

Cardiac resynchronization therapy (CRT) has traditionally been reserved for patients with left ventricular (LV) dysfunction in the setting of advanced heart failure. Early clinical trials clearly demonstrated reverse ventricular remodeling and clinical benefits following CRT in this population. More recently, with the publication of the REVERSE, MADIT-CRT, and RAFT trials, the benefits of CRT have been demonstrated in patients with LV dysfunction and mild heart failure calling into question the optimal timing for biventricular pacemaker implantation. With the expanded indications for CRT arising from these studies, significant questions remain specifically with regards to the economic impact on health care systems and to the added risk of future morbidity due to device infection and malfunction.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalJournal of Interventional Cardiac Electrophysiology
Volume31
Issue number1
DOIs
StatePublished - Jun 2011
Externally publishedYes

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Keywords

  • Biventricular pacing
  • Cardiac resynchronization therapy
  • Cardiomyopathy
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Pivotal trials of cardiac resynchronization therapy : Evolution to therapy in mild heart failure. / Rickard, John; Wilkoff, Bruce Larry.

In: Journal of Interventional Cardiac Electrophysiology, Vol. 31, No. 1, 06.2011, p. 61-68.

Research output: Contribution to journalArticle