Pituitary-Thyroid Feedback

Richard P. Levy, Solomon H. Snyder

Research output: Contribution to journalLetterpeer-review


To the Editor: In his review of receptors, neurotransmitters and drug responses,1 Snyder makes an undocumented assertion about thyroid hormone that deserves rebuttal. He states: “Persons who chronically ingest thyroid hormone gradually become tolerant to its effects because of homeostatic feedback mechanisms involving the pituitary and thyroid glands.” This claim is not supported by clinical experience or experimental evidence. Many years ago we demonstrated that thyroid responsiveness to a single dose of thyroid-stimulating hormone was well maintained after many years of thyroid feeding.2 Krugman et al.3 studied thyroidal uptake of radioactive iodine and pituitary responsiveness to thyrotropin-releasing hormone in 13.

Original languageEnglish (US)
Pages (from-to)1439-1440
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Jun 21 1979

ASJC Scopus subject areas

  • Medicine(all)


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