Pituitary Hypoplasia

Mariam Gangat, Sally Radovick

Research output: Contribution to journalArticlepeer-review

Abstract

This review summarizes pituitary development and function as well as specific mutations of genes encoding the following transcription factors: HESX1, LHX3, LHX4, POU1F1, PROP1, and OTX2. Although several additional genetic defects related to hypopituitarism have been identified, this review focuses on these selected factors, as they have been well described in the literature in terms of clinical characterization of affected patients and molecular mechanisms of action, and therefore, are very relevant to clinical practice.

Original languageEnglish (US)
JournalEndocrinology and Metabolism Clinics of North America
DOIs
StateAccepted/In press - 2017

Keywords

  • Combined pituitary hormone deficiency
  • Hypopituitarism
  • Pituitary development
  • Transcription factor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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