Pituitary autoimmunity in patients with diabetes mellitus and other endocrine disorders

I. Lupi, V. Raffaelli, G. Di Cianni, P. Caturegli, L. Manetti, A. M. Ciccarone, F. Bogazzi, S. Mariotti, S. Del Prato, E. Martino

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Pituitary autoimmunity is often found in association with other endocrine autoimmune or non-autoimmune diseases. Aim of the study was to assess the prevalence of serum pituitary antibodies (PitAb) in patients with Type 1 diabetes mellitus (T1DM) or Type 2 diabetes mellitus (T2DM). Research design and methods: In this casecontrol study 111 patients with T1DM, 110 patients with T2DM, and 214 healthy controls were enrolled in a tertiary referral center. Pituitary, thyroperoxidase, thyroglobulin, 21-hydroxylase, and parietal cell antibodies were assessed in all cases. Endocrine function was further assessed by basal hormone measurement and by dynamic tests, as well as a pituitary magnetic resonance imaging (MRI) was performed in those patients found positive for PitAb. Results: PitAb prevalence was higher in T1DM (4 out of 111, 3.6%) than in T2DM (0 out of 110, p=0.045) and in healthy subjects (1 out of 214, 0.5% p=0.029). Prevalence of other autoimmune diseases was significantly higher in patients with T1DM (45 out of 111, 40.5%) when compared with patients with T2DM (18 out of 110 T2DM, 16.3%, p<0.001). Patients with T1DM and PitAb positivity were found with a pituitary lesion at MRI in 2 cases and pituitary dysfunction in one case. Conclusions: A significant association between pituitary autoimmunity and T1DM was found, in particular in subjects with one or more other endocrine autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalJournal of endocrinological investigation
Volume36
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Diabetes mellitus
  • Pituitary antibodies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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