Pituitary autoimmunity: 30 years later

Patrizio Caturegli, Isabella Lupi, Melissa Landek-Salgado, Hiroaki Kimura, Noel R. Rose

Research output: Contribution to journalReview articlepeer-review

Abstract

Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typically presents as a mass in the sella turcica. It mimics clinically and radiologically other non-functioning sellar masses, such as the more common pituitary adenoma. Hypophysitis shows a striking temporal association with pregnancy, and it has been recently described during immunotherapies that block CTLA-4. Several candidate pituitary autoantigens have been described in the last decade, although none has proven useful as a diagnostic tool. This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification.

Original languageEnglish (US)
Pages (from-to)631-637
Number of pages7
JournalAutoimmunity Reviews
Volume7
Issue number8
DOIs
StatePublished - Sep 2008

Keywords

  • Hypophysitis
  • Pituitary antibodies
  • Pituitary antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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