TY - JOUR
T1 - Pituitary autoimmunity
T2 - 30 years later
AU - Caturegli, Patrizio
AU - Lupi, Isabella
AU - Landek-Salgado, Melissa
AU - Kimura, Hiroaki
AU - Rose, Noel R.
N1 - Funding Information:
The work was supported in part by NIH grant DK55670 to PC.
PY - 2008/9
Y1 - 2008/9
N2 - Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typically presents as a mass in the sella turcica. It mimics clinically and radiologically other non-functioning sellar masses, such as the more common pituitary adenoma. Hypophysitis shows a striking temporal association with pregnancy, and it has been recently described during immunotherapies that block CTLA-4. Several candidate pituitary autoantigens have been described in the last decade, although none has proven useful as a diagnostic tool. This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification.
AB - Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typically presents as a mass in the sella turcica. It mimics clinically and radiologically other non-functioning sellar masses, such as the more common pituitary adenoma. Hypophysitis shows a striking temporal association with pregnancy, and it has been recently described during immunotherapies that block CTLA-4. Several candidate pituitary autoantigens have been described in the last decade, although none has proven useful as a diagnostic tool. This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification.
KW - Hypophysitis
KW - Pituitary antibodies
KW - Pituitary antigens
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U2 - 10.1016/j.autrev.2008.04.016
DO - 10.1016/j.autrev.2008.04.016
M3 - Review article
C2 - 18774118
AN - SCOPUS:50949125774
SN - 1568-9972
VL - 7
SP - 631
EP - 637
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 8
ER -