Pirt functions as an endogenous regulator of TRPM8

Zongxiang Tang; Andrew Kim; Thorsten Masuch; Kyoungsook Park; Hao Jui Weng; Christian Wetzel; Xinzhong Dong

doi:10.1038/ncomms3179

Pirt functions as an endogenous regulator of TRPM8

Zongxiang Tang, Andrew Kim, Thorsten Masuch, Kyoungsook Park, Hao Jui Weng, Christian Wetzel, Xinzhong Dong

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous cells indicate the existence of endogenous modulators of the channel. Here we show that Pirt regulates the function of TRPM8 and its role in detecting cold. Pirt^-/- mice exhibit decreased behavioural responses to cold and cool temperatures, and Pirt increases the sensitivity of TRPM8 to menthol and cool temperature. Our data suggest Pirt is an endogenous regulator of TRPM8.

Original language	English (US)
Article number	2179
Journal	Nature communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms3179
State	Published - Jul 18 2013

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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abstract = "Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous cells indicate the existence of endogenous modulators of the channel. Here we show that Pirt regulates the function of TRPM8 and its role in detecting cold. Pirt-/- mice exhibit decreased behavioural responses to cold and cool temperatures, and Pirt increases the sensitivity of TRPM8 to menthol and cool temperature. Our data suggest Pirt is an endogenous regulator of TRPM8.",

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AU - Tang, Zongxiang

AU - Kim, Andrew

AU - Masuch, Thorsten

AU - Park, Kyoungsook

AU - Weng, Hao Jui

AU - Wetzel, Christian

AU - Dong, Xinzhong

PY - 2013/7/18

Y1 - 2013/7/18

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AB - Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous cells indicate the existence of endogenous modulators of the channel. Here we show that Pirt regulates the function of TRPM8 and its role in detecting cold. Pirt-/- mice exhibit decreased behavioural responses to cold and cool temperatures, and Pirt increases the sensitivity of TRPM8 to menthol and cool temperature. Our data suggest Pirt is an endogenous regulator of TRPM8.

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Pirt functions as an endogenous regulator of TRPM8

Abstract

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