Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice

Seoyoon Choi, Youngshim Choi, Yeji Choi, Sohee Kim, Jeehee Jang, Taesun Park

Research output: Contribution to journalArticle

Abstract

This study examined the effect of piperine on hepatic steatosis and insulin resistance induced in mice by feeding a high-fat diet (HFD) for 13 weeks and elucidated potential underlying molecular mechanisms. Administration of piperine (50 mg/kg body weight) to mice with HFD-induced hepatic steatosis resulted in a significant increase in plasma adiponectin levels. Also, elevated plasma concentrations of insulin and glucose and hepatic lipid levels induced by feeding a HFD were reversed in mice when they were administered piperine. However, piperine did not reduce body weight and other biochemical markers to an extent where they became equal to the levels found in the CD-fed mice. Piperine reversed HFD-induced down-regulation of adiponecitn-AMP-activated protein kinase (AMPK) signalling molecules which play an important role in mediating lipogenesis, fatty acid oxidation and insulin signalling in the livers of mice. The expressions of lipogenic target genes were decreased, whereas the expression of carnitine palmitoyltransferase 1 (CPT1) gene involved in fatty acid oxidation was increased in the livers of the Pin50 group. Piperine significantly decreased the phosphorylation of insulin receptor substrate-1 (IRS-1) compared with the HFD-fed mice. Administration of piperine appeared to reverse preexisting HFD-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling in mice.

Original languageEnglish (US)
Pages (from-to)3627-3635
Number of pages9
JournalFood Chemistry
Volume141
Issue number4
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

piperine
fatty liver
High Fat Diet
high fat diet
Nutrition
insulin resistance
Insulin Resistance
Fats
Insulin
Liver
mice
AMP-activated protein kinase
AMP-Activated Protein Kinases
adiponectin
beta oxidation
Adiponectin
liver
insulin
Fatty Acids
Genes

Keywords

  • Adiponectin-AMPK signalling
  • Fatty acid oxidation
  • Fatty liver
  • Insulin signalling
  • Lipogenesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

Cite this

Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. / Choi, Seoyoon; Choi, Youngshim; Choi, Yeji; Kim, Sohee; Jang, Jeehee; Park, Taesun.

In: Food Chemistry, Vol. 141, No. 4, 01.01.2013, p. 3627-3635.

Research output: Contribution to journalArticle

Choi, Seoyoon ; Choi, Youngshim ; Choi, Yeji ; Kim, Sohee ; Jang, Jeehee ; Park, Taesun. / Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. In: Food Chemistry. 2013 ; Vol. 141, No. 4. pp. 3627-3635.
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