Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP

Uwe Konietzko, Gunther Kauselmann, Joey Scafidi, Ursula Staubli, Harald Mikkers, Anton Berns, Michaela Schweizer, Robert Waltereit, Dietmar Kuhl

Research output: Contribution to journalArticlepeer-review

Abstract

In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmission and short-term plasticity. However, they fail to consolidate enduring LTP even though Pim-2 and Pim-3 are constitutively expressed in the hippocampus and Pim-3 expression is similarly induced by synaptic activity. Thus, expression of Pim-1 is required for LTP. Its level of expression and, consequently, its capacity to phosphorylate target proteins in dendritic and nuclear compartments of stimulated neurons might be a determining factor for the establishment of long-lasting changes in synaptic strength.

Original languageEnglish (US)
Pages (from-to)3359-3369
Number of pages11
JournalEMBO Journal
Volume18
Issue number12
DOIs
StatePublished - Jun 15 1999
Externally publishedYes

Keywords

  • Gene induction
  • Knockout
  • LTP
  • Pim kinase
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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