PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.

Zhuyan Guo, Anlai Wang, Weidong Zhang, Mikhail Levit, Qiang Gao, Claude Barberis, Michel Tabart, Jingxin Zhang, Dietmar Hoffmann, Dmitri Wiederschain, Jennifer Rocnik, Fangxian Sun, Josh Murtie, Christoph Lengauer, Stefan Gross, Bailin Zhang, Hong Cheng, Vinod Patel, Laurent Schio, Francisco AdrianMarion Dorsch, Carlos Garcia-Echeverria, Shih Min A Huang

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Medicine & Life Sciences

Chemical Compounds