Pilot study with weekly chemotherapy for patients with extensive small cell lung cancer: An eastern cooperative oncology group study (PA586)

Alan R. Yuen, Joachim Z. Fuks, David S. Ettinger, Alex Y. Chang, John C. Ruckdeschel, Chun Phan, Ronald H. Blum

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: Six of the most active chemotherapy agents in small cell lung cancer were administered sequentially in a weekly fashion in an attempt to optimize the dose and the number of agents received over a 12-week period. The purpose of this study was to estimate the efficacy and to characterize the toxicity of this approach. PATIENTS AND METHODS: Thirty-six patients with extensive-stage small cell lung cancer received weekly treatments with cisplatin and etoposide (weeks 1, 5, and 11), cyclophosphamide (weeks 2, 7, and 10), vincristine (weeks 2, 4, 7, 8, 10, and 12), methotrexate (weeks 3, 6, and 9), and doxorubicin (weeks 4, 8, and 12). Patients achieving a partial response received a second 12-week course. Patients achieving a complete response received prophylactic cranial radiation. RESULTS: Twenty-nine of the 36 patients completed the initial 12-week program over a median of 16 weeks. Hematologic toxicity was most prominent, with two deaths from sepsis and 31 patients having grade 3 or 4 neutropenia. The overall response rate was 85%, with 33% of patients achieving a complete response. The median survival was 10.5 months, and the median time to progression was 8.2 months. DISCUSSION: This 12-week program, consisting of administration of six active agents for small cell lung cancer, caused significant myelosuppression that resulted in significant treatment delays and dose reductions. Although a high response rate was achieved, the median overall survival of 10.5 months was not significantly longer than expected from other standard two- to three-drug regimens.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalCancer Journal from Scientific American
Volume6
Issue number1
StatePublished - Jan 2000

Keywords

  • Dose intensity
  • Extensive stage small cell lung cancer
  • Lung cancer
  • Weekly chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Pilot study with weekly chemotherapy for patients with extensive small cell lung cancer: An eastern cooperative oncology group study (PA586)'. Together they form a unique fingerprint.

Cite this