Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner

Anja Müller-Lutz, Nadia Khalil, Benjamin Schmitt, Vladimir Jellus, Gael Pentang, Georg Oeltzschner, Gerald Antoch, Rotem S. Lanzman, Hans Jörg Wittsack

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Objective: The objective of this study was to show the feasibility to perform Iopamidol-based pH imaging via clinical 3T magnetic resonance imaging (MRI) using chemical exchange saturation transfer (CEST) imaging with pulse train presaturation.

Materials and methods: The pulse train presaturation scheme of a CEST sequence was investigated for Iopamidol-based pH measurements using a 3T magnetic resonance (MR) scanner. The CEST sequence was applied to eight tubes filled with 100-mM Iopamidol solutions with pH values ranging from 5.6 to 7.0. Calibration curves for pH quantification were determined. The dependence of pH values on the concentration of Iopamidol was investigated. An in vivo measurement was performed in one patient who had undergone a previous contrast-enhanced computed tomography (CT) scan with Iopamidol. The pH values of urine measured with CEST MRI and with a pH meter were compared.

Results: In the measured pH range, pH imaging using CEST imaging with pulse train presaturation was possible. Dependence between the pH value and the concentration of Iopamidol was not observed. In the in vivo investigation, the pH values in the human bladder measured by the Iopamidol CEST sequence and in urine were consistent.

Conclusion: Our study shows the feasibility of using CEST imaging with Iopamidol for quantitative pH mapping in vitro and in vivo on a 3T MR scanner.

Original languageEnglish (US)
Pages (from-to)477-485
Number of pages9
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number6
StatePublished - Nov 22 2014
Externally publishedYes


  • Chemical exchange saturation transfer (CEST)
  • Iopamidol
  • Magnetic resonance imaging (MRI)
  • pH quantification
  • pH-responsive contrast agent

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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