Pilot study of interferon gamma for chronic hepatitis C

Alejandro Soza, Theo Heller, Marc Ghany, Glen Lutchman, T. Jake Liang, June Germain, Henry H. Hsu, Yoon Park, Jay H. Hoofnagle

Research output: Contribution to journalArticle

Abstract

Background/Aims: Currently, there are no effective therapies available for patients with chronic hepatitis C who have failed to respond to optimal interferon alfa-based regimens. The aims of this pilot study were to assess the antiviral activity and safety of interferon gamma in chronic hepatitis C. Methods: Patients with chronic hepatitis C, genotype 1, who had not responded to or who had relapsed after therapy with interferon alfa and ribavirin were enrolled in a trial of interferon gamma 1b given in doses of 100, 200 or 400 μg subcutaneously three times weekly for 4 weeks. Frequent blood samples were obtained for HCV RNA levels. Results: Fourteen patients were enrolled. Geometric mean HCV RNA levels remained unchanged. Serum aminotransferase levels also did not change, while there were significant decreases in neutrophil counts (-41% from baseline) and hematocrit (-5%). Low grade fever and malaise were common with the first injection of interferon gamma, but no serious side effects were encountered. Conclusions: Although relatively well tolerated, interferon gamma in doses of 100-400 μg thrice weekly had no effect on HCV RNA levels in patients with chronic hepatitis C who had failed to achieve a sustained response to interferon alfa-based therapies.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalJournal of Hepatology
Volume43
Issue number1
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Antiviral therapy
  • Bone marrow suppression
  • Cytokines
  • Interferon alfa
  • Interferon gamma
  • Viral kinetics

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Soza, A., Heller, T., Ghany, M., Lutchman, G., Liang, T. J., Germain, J., Hsu, H. H., Park, Y., & Hoofnagle, J. H. (2005). Pilot study of interferon gamma for chronic hepatitis C. Journal of Hepatology, 43(1), 67-71. https://doi.org/10.1016/j.jhep.2005.02.023