Pilot study of a novel therapeutic approach for refractory advanced stage folliculotropic mycosis fungoides

Christina A. Del Guzzo, Neha N. Jariwala, Paul L. Haun, Kelly M. Macarthur, Christen M. Mowad, Elisabeth G. Richard, Joseph P. Holton, Alain H. Rook

Research output: Contribution to journalArticlepeer-review

Abstract

Folliculotropic mycosis fungoides is a variant of cutaneous T-cell lymphoma characterized as having a fol-liculocentric infiltrate of malignant T cells along with a worse prognosis in comparison to the epidermotropic variants. Patients with advanced forms of folliculotro-pic mycosis fungoides are often poorly responsive to both skin-directed as well as to systemic therapies. We report here a high response rate using a novel therapeutic regimen combining interferon gamma, isotreti-noin in low dose and topical carmustine, and in some cases concomitant skin-directed therapies, among 6 consecutive patients with refractory folliculotropic mycosis fungoides with stages IB through IIIB who had previously failed both topical and systemic thera-pies. The potential mechanisms of this multimodality approach are discussed.

Original languageEnglish (US)
Article numberadv00187
Pages (from-to)1-5
Number of pages5
JournalActa Dermato-Venereologica
Volume100
Issue number13
DOIs
StatePublished - Jun 2020

Keywords

  • Carmustine
  • Cutaneous T-cell lymphoma
  • Folliculotropic mycosis fungoides
  • Interferon-gamma
  • Isotretinoin
  • Therapeutic approach

ASJC Scopus subject areas

  • Dermatology

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