Pilot randomized controlled trial of a comprehensive smoking cessation intervention for patients with upper aerodigestive cancer undergoing radiotherapy

Eleni M. Rettig, Carole Fakhry, Russell Hales, Flora Kisuule, Harry Quon, Ana Ponce Kiess, Linda X. Yin, Yuehan Zhang, Amanda L. Blackford, M. Bradley Drummond, Christine Gourin, Wayne Martin Koch, David W Eisele, Gypsyamber D'Souza

Research output: Contribution to journalArticle

Abstract

Background: Smoking among patients with cancer is associated with poor outcomes, however, smoking cessation interventions have had limited success. Methods: This randomized controlled trial compared a novel smoking cessation intervention ("intervention") with enhanced usual care ("control"). Participants were smokers with head and neck or thoracic malignancies undergoing radiation. Controls received brief counseling. Intervention participants received intensive counseling, pharmacotherapy, text-messaging, and financial incentives. Biochemically confirmed 7-day abstinence at 8 weeks was compared using Fisher's exact t test. Smoking abstinence and intensity were also analyzed using time-series panel regression. Results: The study population comprised 19 intervention and 10 control participants. More intervention (74%) than control (30%) participants abstained from smoking at 8 weeks (P = .05). Intervention participants were significantly more likely to abstain (adjusted odds ratio [OR] 14.70; 95% confidence interval [CI] 3.56-60.76) and smoked fewer cigarettes (adjusted incidence rate ratio [IRR], 0.16; 95% CI 0.06-0.40) during weeks 1 to 8. Conclusion: This intervention decreased smoking among patients with upper aerodigestive cancers during radiotherapy.

Original languageEnglish (US)
JournalHead and Neck
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Smoking Cessation
Radiotherapy
Randomized Controlled Trials
Smoking
Counseling
Neoplasms
Text Messaging
Confidence Intervals
Tobacco Products
Motivation
Neck
Thorax
Odds Ratio
Head
Radiation
Drug Therapy
Incidence
Population

Keywords

  • Head and neck cancer
  • Lung cancer
  • Radiotherapy
  • Smoking cessation intervention
  • Tobacco dependence

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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title = "Pilot randomized controlled trial of a comprehensive smoking cessation intervention for patients with upper aerodigestive cancer undergoing radiotherapy",
abstract = "Background: Smoking among patients with cancer is associated with poor outcomes, however, smoking cessation interventions have had limited success. Methods: This randomized controlled trial compared a novel smoking cessation intervention ({"}intervention{"}) with enhanced usual care ({"}control{"}). Participants were smokers with head and neck or thoracic malignancies undergoing radiation. Controls received brief counseling. Intervention participants received intensive counseling, pharmacotherapy, text-messaging, and financial incentives. Biochemically confirmed 7-day abstinence at 8 weeks was compared using Fisher's exact t test. Smoking abstinence and intensity were also analyzed using time-series panel regression. Results: The study population comprised 19 intervention and 10 control participants. More intervention (74{\%}) than control (30{\%}) participants abstained from smoking at 8 weeks (P = .05). Intervention participants were significantly more likely to abstain (adjusted odds ratio [OR] 14.70; 95{\%} confidence interval [CI] 3.56-60.76) and smoked fewer cigarettes (adjusted incidence rate ratio [IRR], 0.16; 95{\%} CI 0.06-0.40) during weeks 1 to 8. Conclusion: This intervention decreased smoking among patients with upper aerodigestive cancers during radiotherapy.",
keywords = "Head and neck cancer, Lung cancer, Radiotherapy, Smoking cessation intervention, Tobacco dependence",
author = "Rettig, {Eleni M.} and Carole Fakhry and Russell Hales and Flora Kisuule and Harry Quon and Kiess, {Ana Ponce} and Yin, {Linda X.} and Yuehan Zhang and Blackford, {Amanda L.} and Drummond, {M. Bradley} and Christine Gourin and Koch, {Wayne Martin} and Eisele, {David W} and Gypsyamber D'Souza",
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doi = "10.1002/hed.25148",
language = "English (US)",
journal = "Head and Neck Surgery",
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T1 - Pilot randomized controlled trial of a comprehensive smoking cessation intervention for patients with upper aerodigestive cancer undergoing radiotherapy

AU - Rettig, Eleni M.

AU - Fakhry, Carole

AU - Hales, Russell

AU - Kisuule, Flora

AU - Quon, Harry

AU - Kiess, Ana Ponce

AU - Yin, Linda X.

AU - Zhang, Yuehan

AU - Blackford, Amanda L.

AU - Drummond, M. Bradley

AU - Gourin, Christine

AU - Koch, Wayne Martin

AU - Eisele, David W

AU - D'Souza, Gypsyamber

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Smoking among patients with cancer is associated with poor outcomes, however, smoking cessation interventions have had limited success. Methods: This randomized controlled trial compared a novel smoking cessation intervention ("intervention") with enhanced usual care ("control"). Participants were smokers with head and neck or thoracic malignancies undergoing radiation. Controls received brief counseling. Intervention participants received intensive counseling, pharmacotherapy, text-messaging, and financial incentives. Biochemically confirmed 7-day abstinence at 8 weeks was compared using Fisher's exact t test. Smoking abstinence and intensity were also analyzed using time-series panel regression. Results: The study population comprised 19 intervention and 10 control participants. More intervention (74%) than control (30%) participants abstained from smoking at 8 weeks (P = .05). Intervention participants were significantly more likely to abstain (adjusted odds ratio [OR] 14.70; 95% confidence interval [CI] 3.56-60.76) and smoked fewer cigarettes (adjusted incidence rate ratio [IRR], 0.16; 95% CI 0.06-0.40) during weeks 1 to 8. Conclusion: This intervention decreased smoking among patients with upper aerodigestive cancers during radiotherapy.

AB - Background: Smoking among patients with cancer is associated with poor outcomes, however, smoking cessation interventions have had limited success. Methods: This randomized controlled trial compared a novel smoking cessation intervention ("intervention") with enhanced usual care ("control"). Participants were smokers with head and neck or thoracic malignancies undergoing radiation. Controls received brief counseling. Intervention participants received intensive counseling, pharmacotherapy, text-messaging, and financial incentives. Biochemically confirmed 7-day abstinence at 8 weeks was compared using Fisher's exact t test. Smoking abstinence and intensity were also analyzed using time-series panel regression. Results: The study population comprised 19 intervention and 10 control participants. More intervention (74%) than control (30%) participants abstained from smoking at 8 weeks (P = .05). Intervention participants were significantly more likely to abstain (adjusted odds ratio [OR] 14.70; 95% confidence interval [CI] 3.56-60.76) and smoked fewer cigarettes (adjusted incidence rate ratio [IRR], 0.16; 95% CI 0.06-0.40) during weeks 1 to 8. Conclusion: This intervention decreased smoking among patients with upper aerodigestive cancers during radiotherapy.

KW - Head and neck cancer

KW - Lung cancer

KW - Radiotherapy

KW - Smoking cessation intervention

KW - Tobacco dependence

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